SML2966
Z-RLRGG-AMC Acetate
≥95% (HPLC)
Synonym(s):
N2-[(Phenylmethoxy)carbonyl]-L-arginyl-L-leucyl-L-arginylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-glycinamide, Z-Arg-Leu-Arg-Gly-Gly-7-amido-4-methylcoumarin, Z-Arg-Leu-Arg-Gly-Gly-AMC
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About This Item
Empirical Formula (Hill Notation):
C40H56N12O9 · xC2H4O2
CAS Number:
Molecular Weight:
848.95 (free base basis)
UNSPSC Code:
12352209
NACRES:
NA.77
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Biochem/physiol Actions
Z-RLRGG-AMC is a fluorogenic substrate for the MERS-CoV, SARS-CoV, SARS-CoV-2 papain-like protease (PLpros), deubiquitinating enzyme isopeptidase T (IPaseT) and other ubiquitin C-terminal hydrolases, which consists of the Ub and ISG15 C-terminal sequences. Z-RLRGG-AMC excitation wavelength is 340 nm, and emission wavelength is 460 nm.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Yahira M Báez-Santos et al.
Journal of virology, 88(21), 12511-12527 (2014-08-22)
The papain-like protease (PLpro) domain from the deadly Middle East respiratory syndrome coronavirus (MERS-CoV) was overexpressed and purified. MERS-CoV PLpro constructs with and without the putative ubiquitin-like (UBL) domain at the N terminus were found to possess protease, deubiquitinating, deISGylating
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