SCP0196

Myosin Light Chain Kinase Substrate

≥95% (HPLC), lyophilized

• Empirical Formula (Hill Notation): C₆₁H₁₀₇N₂₃O₁₆
• Molecular Weight: 1418.65
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• product name: Myosin Light Chain Kinase Substrate (smooth muscle),
• Assay: ≥95% (HPLC)
• form: lyophilized
• composition: Peptide Content, ≥62%
• storage condition: protect from light
• storage temp.: −20°C

Description

Amino Acid Sequence

Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-Asn-Val-Phe-Ala-NH2

General description

Myosin light chain kinase (MLCK) comprises an N-terminal actin-binding domain, a central kinase domain, and a C-terminal myosin-binding domain.

Application

Myosin Light Chain Kinase Substrate (smooth muscle) has been used in MLCK activity assay to study the role of Plasmodium falciparum calmodulin (Pf CaM).

Biochem/physiol Actions

KKRAARATSNVFA-NH2 is used as a myosin light chain kinase (MLCK) substrate.

Myosin light chain kinase (MLCK) is involved in modulating the actin-myosin interaction of smooth muscle. In addition to its kinase activity, MLCK also has actin-binding activity, which can assemble actin filaments into bundles. It also has myosin-binding activity, which can generate myosin filaments.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable