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About This Item
Empirical Formula (Hill Notation):
C119H180N32O33
Molecular Weight:
2586.90
UNSPSC Code:
12352209
NACRES:
NA.32
Recommended Products
Assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥72%
storage condition
protect from light
storage temp.
−20°C
Amino Acid Sequence
His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser
Application
Endothelin Big (1-38) is the precursor of Endothelin 1. [D-Val22]-Endothelin-1 Big fragment (16-38) is used to inhibit endothelin-converting enzyme activity.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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G C Hanson et al.
Regulatory peptides, 68(1), 63-69 (1997-01-15)
The hydrolysis of human big endothelin 1-38 (bigET-1) was investigated in the membrane fractions from three human lung specimens. The hydrolysis products were identified by HPLC or by amino acid analysis, peptide sequencing and mass spectrometry, and the contractile effects
Marie-Hélène Fecteau et al.
Hypertension (Dallas, Tex. : 1979), 46(1), 87-92 (2005-06-16)
The precursor of endothelin-1, big endothelin-1, can be hydrolyzed by chymase to generate endothelin-1 (1-31) in vitro. In the present study, we explored the processes involved in the production of endothelin-1 (1-31) as well as its pharmacodynamic characteristics in the
Michael Zimmermann et al.
Neurosurgical review, 26(2), 125-132 (2003-09-10)
The aim of this study was to investigate whether the blocking of endothelin-converting enzyme (ECE) activity offers a new approach to inhibiting the development of cerebral vasospasm after subarachnoid hemorrhage (SAH) by preventing transformation of big endothelin-1 (big ET-1) to
Vasileios Kalles et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 33(4), 1231-1236 (2012-03-15)
Deregulation of the endothelin system, comprised of endothelin-1 (ET-1), its isoforms (ET-2 and ET-3) and their receptors (ET(A)R and ET(B)R), is under investigation in various types of human cancer. ET-1 has been suggested to participate in breast cancer development and
A Morita et al.
FEBS letters, 353(1), 84-88 (1994-10-10)
Endothelin converting enzyme (ECE) is essential for generation of the biological effects of endothelin-1 (ET-1) from a precursor, big endothelin-1 (Big ET-1). We synthesized four analogs of human Big ET-1[16-38], substituted with single D-amino acids at P1, P2, P1' and
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