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About This Item
Empirical Formula (Hill Notation):
C15H8ClF5N2O3
CAS Number:
Molecular Weight:
394.68
MDL number:
UNSPSC Code:
51112008
NACRES:
NA.76
Recommended Products
Quality Level
form
powder
antibiotic activity spectrum
Gram-positive bacteria
Mode of action
protein synthesis | interferes
storage temp.
−20°C
SMILES string
FC1(Oc2c(ccc(c2)NC(=O)Nc3cc(c(cc3)Cl)C(F)(F)F)O1)F
InChI
1S/C15H8ClF5N2O3/c16-10-3-1-7(5-9(10)14(17,18)19)22-13(24)23-8-2-4-11-12(6-8)26-15(20,21)25-11/h1-6H,(H2,22,23,24)
General description
PK150 is a recently discovered small antimicrobial compound. It is a potent analog of sorafenib, an anticancer drug. PK150 has structural similarity with triclocarban (TCC) and triclosan (TCS) with a N,N′-diaryl urea motif in common.
Biochem/physiol Actions
PK150 is a potent antibiotic, which displays strong antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) at a sub-micromolar level. It elicits anti-biofilm activity and eliminates persisters. PK150 also shows oral bioavailability, and in vivo efficacy in mouse model.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Philipp Le et al.
Nature chemistry, 12(2), 145-158 (2019-12-18)
New drugs are desperately needed to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Here, we report screening commercial kinase inhibitors for antibacterial activity and found the anticancer drug sorafenib as major hit that effectively kills MRSA strains. Varying the key structural
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