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Key Documents

SAB5702697

Sigma-Aldrich

Anti-AHA1 Antibody, clone 8E5H7, Rabbit Monoclonal

Synonym(s):

AHA1, C14orf3, hAha1, p38

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.46
clone:
8E5H7, monoclonal
application:
WB
species reactivity:
human, rat, rat
technique(s):
western blot: 1:500 - 1:2000
citations:

biological source

rabbit

Quality Level

material

colorless

clone

8E5H7, monoclonal

form

liquid

mol wt

42 kDa

species reactivity

human, rat, rat

concentration

0.58 mg/mL

technique(s)

western blot: 1:500 - 1:2000

color

colorless

isotype

IgG

immunogen sequence

PATLEADRGGKFHMVDGNVSGEFTDLVPEKHIVMKWRFKSWPEGHFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYGARLF

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... AHSA1(10598)

General description

AHA-1 stimulates the inherent ATPase activity of yeast and human HSP 90 and interacts with the cytoplasmic tail of vesticular stomatitis virus glycoprotein. AHA-1 regulates HSP 90 by influencing the conformational state of the “ATP lid” and consequent N-terminal dimerization. It is crucial for cell viability under non-optimal growth conditions when HSP 90 levels are limiting. AHA-1 is a cytosolic protein and may transiently interact with the endoplasmic reticulum. It can have an affect on one step in the endoplasmic to Golgi trafficking. AHA-1 is expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, in liver and placenta. It is induced by heat shock and treatment with the HSP 90 inhibitor 17-demeth-oxygeldanamycin.

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 239-338 of human AHA1 (O95433).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Application

WB

Storage Class Code

10 - Combustible liquids

WGK

WGK 1


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