S7010
Span® 60
Synonym(s):
Sorbitan stearate, Sorbitane monostearate
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All Photos(3)
About This Item
CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12161900
PubChem Substance ID:
NACRES:
NA.25
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description
non-ionic
Quality Level
mol wt
430.63 g/mol
concentration
45-55% (GC)
SMILES string
CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O
InChI
1S/C24H46O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h20-21,23-26,28H,2-19H2,1H3/t20-,21?,23+,24+/m0/s1
InChI key
HVUMOYIDDBPOLL-XGKPLOKHSA-N
Related Categories
General description
Span® 60 is a sorbitan monoester than is used as a non-ionic detergent.
Application
Span® 60 has been used in a study to assess encapsulation of doxorubicin in niosomes as a route to tumor targeting. It has also been used in a study to investigate the use of nonionic surfactants as contrast agents for use in diagnostic ultrasounds.
Other Notes
Fatty acid composition: Stearic acid (C18:0) approx. 50%; balance primarily palmitic acid (C16:0).
Legal Information
Span is a registered trademark of Croda International PLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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I F Uchegbu et al.
Pharmaceutical research, 12(7), 1019-1024 (1995-07-01)
Encapsulation of doxorubicin in niosomes was sought as a route to tumour targeting and improved tumoricidal through the alteration of doxorubicin pharmacokinetics and metabolism. Doxorubicin niosomes (10 mg kg-1 doxorubicin) prepared from sorbitan monostearate (Span 60), cholesterol and choleth-24 (a
Preparation and properties of vesicles (niosomes) of sorbitan monoesters ([TM="Span"] 20, 40, 60 and 80) and a sorbitan triester ([TM="Span"] 85).
Yoshioka, T., et al.
International Journal of Pharmaceutics, 105, 1-1 (1994)
Surfactant-stabilized microbubbles as ultrasound contrast agents: stability study of [TM="Span"] 60 and Tween 80 mixtures using a Langmuir trough
Singhal, S., et al.
Langmuir, 9, 2426-2426 (1993)
Karimunnisa Sameer Shaikh et al.
Drug development and industrial pharmacy, 36(8), 946-953 (2010-03-04)
Niosomal delivery can prove an alternative to improve the poor skin penetration and residence of the topical antifungal drugs that account for the long treatment regimes in cutaneous mycosis. To investigate niosomes as carriers for dermal delivery of ciclopirox olamine
A Manosroi et al.
International journal of pharmaceutics, 356(1-2), 291-299 (2008-02-19)
Characteristics and physical stability of luciferase plasmid (pLuc) entrapped in cationic bilayer vesicles prepared from various molar ratios of amphiphiles (DPPC, Tween61 or Span60), cholesterol (Chol) and cationic charge lipid (DDAB) were investigated. The cationic liposomes were composed of DPPC/Chol/DDAB
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