P2658

Poly-L-lysine hydrochloride

suitable for cell culture, Mol wt 15,000-30,000

• Synonym(s): L-Lysine hydrochloride homopolymer
• CAS Number: 26124-78-7
• MDL number: MFCD00081870
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• NACRES: NA.26

Properties

• product name: Poly-L-lysine hydrochloride, mol wt 15,000-30,000
• form: powder or solid
• Quality Level: 200
• mol wt: 15,000-30,000
• technique(s): cell culture | mammalian: suitable
• color: white to light yellow
• application(s): cell analysis
• storage temp.: −20°C

Description

Application

Poly-L-lysine hydrochloride has been used to coat glass slides and coverslips to facilitate cell attachment.

Poly-lysine with mol. wt. >70,000 is useful in promoting cell adhesion to solid substrates.

Biochem/physiol Actions

L-Lysine is believed to prevent osteoporosis of bones, which is a characteristics of vascular calcification. Glutaric aciduria type I and pyridoxine-dependent epilepsy occurs due to lack of L-lysine catabolic pathway. Lysine participates in the regulation of NO (nitric oxide) synthesis. It possesses antiviral activity, therefore it is used in the treatment of Herpes simplex. L-Lysine is associated with a number of biochemical reactions such as acetylation, O-linked glycosylation, ubiquitination and protein methylation. Poly-L-lysine is considered as a biocompatible polymer and serves for the purpose of drug delivery across cell membrane. It is useful as one of the nanosized contrast agents in MRI (magnetic resonance imaging).

Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves