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O4386

Sigma-Aldrich

L-Ornithine monohydrochloride

BioXtra, ≥99%

Synonym(s):

(S)-2,5-Diaminopentanoic acid monohydrochloride

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About This Item

Empirical Formula (Hill Notation):
C5H12N2O2 · HCl
CAS Number:
3184-13-2
Molecular Weight:
168.62
Beilstein:
3625847
EC Number:
221-678-6
MDL number:
MFCD00064562
UNSPSC Code:
12352209
PubChem Substance ID:
24897996
NACRES:
NA.26

product line

BioXtra

Quality Level

200

Assay

≥99%

form

powder

impurities

ammonia- and citrulline-free, essentially free
≤0.005% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.1%

color

white

solubility

H2O: 1 M at 20 °C, clear, faintly yellow

anion traces

sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

SMILES string

Cl.NCCC[C@H](N)C(O)=O

InChI

1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1

InChI key

GGTYBZJRPHEQDG-WCCKRBBISA-N

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Biochem/physiol Actions

L-Ornithine is a not encoded by DNA. It is a free amino acid but do not participate in the protein synthesis. It is formed by the action of the enzyme arginase on L-arginine in the process of forming urea. It is implicated in the reduction of blood ammonia level and improves the efficiency of energy production to cause ammonia detoxification. L-ornithine promotes the release of growth hormone by triggering the pituitary gland.

Other Notes

Product of arginine degradation by arginase

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism
Sugino T, et al.
Nutrition Research (New York, N.Y.), 28(11), 738-743 (2008)
The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise
Demura S, et al.
European Journal of Clinical Nutrition, 64(10), 1166-1171 (2010)
Sherry Dadsetan et al.
Biochemical pharmacology, 85(1), 115-123 (2012-10-30)
Combined administration of ornithine and phenylacetate (OP) is proposed as a novel treatment of hyperammonemia and hepatic encephalopathy. Ornithine is believed to increase ammonia fixation into glutamine in muscle tissue and glutamine is subsequently thought to react with phenylacetate forming
Nicole Berthold et al.
Antimicrobial agents and chemotherapy, 57(1), 402-409 (2012-11-02)
Proline-rich antimicrobial peptides (PrAMPs) from insects and mammals have recently been evaluated for their pharmaceutical potential in treating systemic bacterial infections. Besides the native peptides, several shortened, modified, or even artificial sequences were highly effective in different murine infection models.
Charles D Mills
Critical reviews in immunology, 32(6), 463-488 (2013-02-23)
The purpose of immunology is simple. Cure or prevent disease. M1/M2 is useful because it is simple. M1/M2 describes the two major and opposing activities of macrophages. M1 activity inhibits cell proliferation and causes tissue damage while M2 activity promotes
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