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N7127

Sigma-Aldrich

DL-Normetanephrine hydrochloride

≥98%

Synonym(s):

DL-α-(Aminomethyl)-4-hydroxy-3-methoxybenzenemethanol hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C9H13NO3 · HCl
CAS Number:
1011-74-1
Molecular Weight:
219.67
EC Number:
213-787-2
MDL number:
MFCD00012882
UNSPSC Code:
12352200
PubChem Substance ID:
24277786
NACRES:
NA.77

Assay

≥98%

form

powder

solubility

H2O: 50 mg/mL

SMILES string

NCC(C1=CC(OC)=C(C=C1)O)O.Cl

InChI

1S/C9H13NO3.ClH/c1-13-9-4-6(8(12)5-10)2-3-7(9)11;/h2-4,8,11-12H,5,10H2,1H3;1H

InChI key

VKFPRGQZWKTEON-UHFFFAOYSA-N

Biochem/physiol Actions

Norepinephrine metabolite.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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G Eisenhofer
Naunyn-Schmiedeberg's archives of pharmacology, 349(3), 259-269 (1994-03-01)
The importance of neuronal reuptake for terminating the actions of noradrenaline is well established, but the role of extraneuronal uptake is less clear. This study used plasma concentrations of the extraneuronal noradrenaline metabolite, normetanephrine, to estimate rates of extraneuronal removal
T Mano et al.
Thyroid : official journal of the American Thyroid Association, 8(4), 353-358 (1998-05-20)
Clinical and experimental data suggest that thyroid hormone affects the actions of catecholamine (CA). However, the serum or tissue levels of CA during thyroid disorders have not been well defined. Accordingly, we investigated the levels of CA and their metabolites
Jiamin Zheng et al.
Analytica chimica acta, 1037, 159-167 (2018-10-08)
A robust, sensitive, high-throughput method for the detection and quantification of catecholamines in serum, including dopamine, 5-methoxytryptamine, tyramine, phenylethylamine (PEA), epinephrine (EPI), norepinephrine (NE), metanephrine (MN), and normetanephrine (NMN) is described. It is based on liquid chromatography-tandem mass spectrometry (LC-MS/MS)
M Tsunoda et al.
Analytical biochemistry, 269(2), 386-392 (1999-05-01)
A highly specific and sensitive automated high-performance liquid chromatographic method for the simultaneous determination of catecholamines (CAs; norepinephrine, epinephrine, and dopamine) and their 3-O-methyl metabolites (normetanephrine, metanephrine, and 3-methoxytyramine) is described. Automated precolumn ion-exchange extraction of diluted plasma is coupled
Sebastiano Barco et al.
Clinical biochemistry, 47(15), 119-121 (2014-07-20)
Measurement of urinary fractionated metanephrines represents a first-line test for the biochemical diagnosis of pheochromocytoma. The high performance liquid chromatography coupled to electrochemical detection (HPLC-EC) assays used in the routine clinical laboratory can be subjected to analytical interferences by the
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