N6287
Nutlin-3
≥98% (HPLC), powder, Mdm2 antagonist
Synonym(s):
(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
About This Item
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product name
Nutlin-3, ≥98% (HPLC), powder
ligand
nutlin-3
Quality Level
Assay
≥98% (HPLC)
form
powder
reaction suitability
reagent type: ligand
solubility
DMSO: 20 mg/mL
H2O: insoluble
originator
Roche
shipped in
wet ice
storage temp.
−20°C
SMILES string
O=C(N1CC(NCC1)=O)N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=C(OC(C)C)C=C(OC)C=C5
InChI
1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m1/s1
InChI key
BDUHCSBCVGXTJM-IZLXSDGUSA-N
Application
- as a drug to stimulate p53 functions in gene transfer experiment
- to inject worms to verify the prevalent role of translationally controlled tumor protein (TCTP) in posterior amputated E. eugeniae
- as a p53 activator in cyclotherapy studies
- as an mdm2 inhibitor to know its effect on p53 levels, cleaved caspase 3 and Poly (ADP-ribose) polymerase (PARP) cleavage
Biochem/physiol Actions
Features and Benefits
Other Notes
Analysis Note
Legal Information
related product
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
Certificates of Analysis (COA)
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