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N4913

Sigma-Aldrich

Anti-NOTCH2 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Notch homolog 2 (Drosophila)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~230 kDa (extracellular)
antigen ~280 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: 1:500-1:1,000

UniProt accession no.

Q04721

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NOTCH2(4853)
mouse ... Notch2(18129)
rat ... Notch2(29492)

General description

NOTCH homolog-2 (NOTCH2) is part of the NOTCH signaling pathway and the gene encoding it is localized on chromosome 1p13-p11.

Immunogen

synthetic peptide corresponding to residues 1718-1733 of human NOTCH2. This sequence is 93% identical in mouse and rat.

Biochem/physiol Actions

NOTCH homolog-2 (NOTCH2) is a stimulator of metaplasia in goblet cells, which is seen in respiratory diseases like asthma. Mutations in the NOTCH2 gene are associated with Hajdu-Cheney syndrome.

Physical form

solution in phosphate buffered saline, containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A novel NOTCH2 mutation identified in a Korean family with Hajdu-Cheney syndrome showing phenotypic diversity.
Han MS
Annals of Clinical and Laboratory Science, 45(1), 110-114 (2015)
Hajdu-Cheney syndrome: a review.
Canalis E and Zanotti S
Orphanet Journal of Rare Diseases, 9, 200-200 (2014)
NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine.
Dong Y
Stem Cells Translational Medicine, 3(12), 1456-1466 (2014)
Henry Danahay et al.
Cell reports, 10(2), 239-252 (2015-01-06)
The balance and distribution of epithelial cell types is required to maintain tissue homeostasis. A hallmark of airway diseases is epithelial remodeling, leading to increased goblet cell numbers and an overproduction of mucus. In the conducting airway, basal cells act
Johan Boström et al.
PloS one, 12(12), e0188772-e0188772 (2017-12-12)
The cell cycle coordinates core functions such as replication and cell division. However, cell-cycle-regulated transcription in the control of non-core functions, such as cell identity maintenance through specific transcription factors (TFs) and signalling pathways remains unclear. Here, we provide a
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