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Key Documents

M0883

Sigma-Aldrich

4-Methylumbelliferyl acetate

esterase substrate

Synonym(s):

MU-Ac

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About This Item

Empirical Formula (Hill Notation):
C12H10O4
CAS Number:
Molecular Weight:
218.21
Beilstein:
189667
EC Number:
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32

Assay

≥98% (TLC)

form

powder

mp

149-150 °C (lit.)

solubility

chloroform: 100 mg/mL, clear, colorless

fluorescence

λex 312 nm in methanol
λex 360 nm; λem 499 nm (Reaction product)

storage temp.

−20°C

SMILES string

CC(=O)Oc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C12H10O4/c1-7-5-12(14)16-11-6-9(15-8(2)13)3-4-10(7)11/h3-6H,1-2H3

InChI key

HXVZGASCDAGAPS-UHFFFAOYSA-N

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Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Enzyme kinetic studies in cell populations using fluorogenic substrates and flow cytometric techniques.
J V Watson
Cytometry, 1(2), 143-151 (1980-09-01)
H G Raj et al.
Bioorganic & medicinal chemistry, 9(5), 1085-1089 (2001-05-30)
Our earlier work established a convenient assay procedure for acetoxycoumarin (AC): protein transacetylase (TA) by indirectly quantifying the activity of glutathione (GSH)-S-transferase (GST), the extent of inhibition of GST under the conditions of the assay represented TA activity. In this
David Sychantha et al.
Biochemistry, 57(16), 2394-2401 (2018-03-30)
Streptococcus pneumoniae among other Gram-positive pathogens produces O-acetylated peptidoglycan using the enzyme OatA. This process occurs through the transfer of an acetyl group from a donor to the hydroxyl group of an acceptor sugar. While it has been established that
A A Frimer et al.
Free radical biology & medicine, 20(6), 843-852 (1996-01-01)
--2-(Dimethylamino) fluorene (1a) and 5-benzoyloxy-2,3,7,8,12,13,17,18-octaethylporphyrin (4) react with superoxide anion radical (generated from KO2/18-crown-6 polyether) in aprotic media. Yet, when incorporated into the lipid bilayer of dimyristoyl phosphatidylcholine liposomes, these two substrates are inert to superoxide, generated enzymatically (xanthine oxidase/acetaldehyde)
H G Raj et al.
Teratogenesis, carcinogenesis, and mutagenesis, 21(2), 181-187 (2001-02-27)
Our earlier studies documented the ability of 7,8-diacetoxy-4-methylcoumarin (DAMC) to cause irreversible inhibition of cytochrome P-450 linked mixed function oxidases (MFO) mediated by membrane bound DAMC: protein transacetylase. Since P-450 catalyzed oxidation of benzene is crucial to its toxic effects

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