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I7908

Sigma-Aldrich

Interleukin-2 human

recombinant, expressed in Pichia pastoris, suitable for cell culture

Synonym(s):

IL-2, Interleukin-2, T-cell growth factor

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About This Item

MDL number:
MFCD00165721
UNSPSC Code:
12352202
NACRES:
NA.75

biological source

human

Quality Level

200

recombinant

expressed in Pichia pastoris

Assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

mol wt

predicted mol wt ~15 kDa

packaging

pkg of 10KU

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P60568

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... IL2(3558)

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Application

Interleukin-2 human has been used to assess changes in tumor necrosis factor receptor 1 (TNFR1). It has also been used in TNFR2 expression on Tregs.

Biochem/physiol Actions

Interleukin 2 (IL2) is a pro-inflammatory cytokine. It consists of three subunits, in which the β subunit is important for receptor mediated signaling. IL2 enhances the development of T regulatory cells and plays a crucial role in antitumor immunity.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Physical form

Lyophilized from a 0.2 μm filtered solution in 50 mM sodium phosphate buffer, pH 7.0, containing 0.1% human serum albumin per 0.1 mL of cytokine.

Analysis Note

The biological activity is tested in a cell proliferation assay using an IL-2 dependent murine cytotoxic T cell line, CTLL-2.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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TNFR1 and TNFR2 expression and induction on human Treg cells from type 1 diabetic subjects
Heinrich M, et al.
Antibodies, 4(1), 34-47 (2015)
Polymorphisms and haplotypes of the interleukin 2 gene are associated with an increased risk of gastric cancer. The possible involvement of Helicobacter pylori
Melchiade, et al.
Cytokine, 96 (2017)
The main function of IL-2 is to promote the development of T regulatory cells
Malek, Th, et al.
Journal of Leukocyte Biology, 74(6) (2003)
The IL-2 receptor complex: its structure, function, and target genes
Minami, Y, et al.
Annual Review of Immunology, 11(1) (1993)
Meera V Singh et al.
Journal of leukocyte biology, 109(4), 807-820 (2020-07-15)
In addition to their role in hemostasis, platelets store numerous immunoregulatory molecules such as CD40L, TGFβ, β2-microglobulin, and IL-1β and release them upon activation. Previous studies indicate that activated platelets form transient complexes with monocytes, especially in HIV infected individuals
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