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A6419

Sigma-Aldrich

Adenosine 5′-triphosphate disodium salt hydrate

microbial, BioReagent, suitable for cell culture, ≥99% (HPLC)

Synonym(s):

ATP disodium salt

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About This Item

Empirical Formula (Hill Notation):
C10H14N5Na2O13P3 · xH2O
CAS Number:
Molecular Weight:
551.14 (anhydrous basis)
MDL number:
UNSPSC Code:
12352207
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.75

Pricing and availability is not currently available.

biological source

microbial

Quality Level

product line

BioReagent

Assay

≥99% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

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General description

Adenosine 5′-triphosphate (ATP) is essential for biological processes including neurotransmission, signal transduction, muscle contraction and cardiac function. ATP is the major energy potential for living systems.[1] They are released from cells under stress and play a key role in immune response.[2] ATP release from injured neurons and consequent breakdown leads to generation of adenosine.[3] ATP may serve as a therapeutic option in anaesthesia and intensive care medicine for the management of pain.[1] Elevated ATP levels are indicative of cell damage and inflammation.[4]

Application

Adenosine 5′-triphosphate disodium salt hydrate has been used:
  • as a component of transfection mix for the transformation of CRISPR/Cas9 plasmid in parasites[5]
  • in inflammasome activation assays in bone marrow derived macrophages[6]
  • for the stimulation of macrophages[7]
  • in nucleotide synthesis[8]

Biochem/physiol Actions

P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Protocols

    Separation of Adenosine 5′-triphosphate disodium salt hydrate, BioXtra, ≥99% (HPLC), from microbial; Adenosine 5′-diphosphate sodium salt, bacterial, ≥95% (HPLC); 2′-Deoxyadenosine 5′-monophosphate, Sigma Grade, 98-100%

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