PHR1530

Acetaminophen Related Compound D

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Acetanilide, N-Phenylacetamide
• Linear Formula: CH₃CONHC₆H₅
• CAS Number: 103-84-4
• Molecular Weight: 135.16
• Beilstein: 606468
• EC Number: 203-150-7
• MDL number: MFCD00008674
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823442
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to USP 1003042
• vapor density: 4.65 (vs air)
• vapor pressure: 1 mmHg ( 114 °C)
• description: API family: acetaminophen
• API family: acetaminophen, paracetamol
• CofA: current certificate can be downloaded
• autoignition temp.: 1004 °F
• packaging: pkg of 200 mg
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• bp: 304 °C (lit.)
• mp: 113-115 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: CC(=O)Nc1ccccc1
• InChI: 1S/C8H9NO/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)
• InChI key: FZERHIULMFGESH-UHFFFAOYSA-N

Description

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

It is an impurity of the widely used antipyretic and analgesic drug acetaminophen, also known as paracetamol.

Application

This pharmaceutical secondary standard can also be used as follows:

• Detection and quantification of paracetamol, phenylephrine hydrochloride, and paracetamol impurities in pharmaceutical formulations using four chemometric-based spectrophotometric methods
• Simultaneous determination of paracetamol and phenylephrine hydrochloride in the presence of paracetamol-related impurities using capillary zone electrophoresis (CZE) in their combined tablet forms

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA3648 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

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Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): 321.8 °F - closed cup
• Flash Point(C): 161 °C - closed cup