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61347

Supelco

10,11-Dihydro-10-hydroxycarbamazepine

analytical standard

Synonym(s):

10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide, Licarbazepine

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5 G
€178.00

€178.00

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5 G
€178.00

About This Item

Empirical Formula (Hill Notation):
C15H14N2O2
CAS Number:
29331-92-8
Molecular Weight:
254.28
Beilstein:
1540211
MDL number:
MFCD00871817
UNSPSC Code:
41116107
PubChem Substance ID:
329759441
NACRES:
NA.24

€178.00

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grade

analytical standard

Quality Level

100

Assay

≥99% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

N1(c2c(cccc2)C(Cc3c1cccc3)O)C(=O)N

InChI

1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)

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Show Differences

1 of 4

This Item
PZ0355PZ0210PZ0211
PF-05212384 ≥98% (HPLC)

PZ0281

PF-05212384

PF-05085727 ≥98% (HPLC)

PZ0355

PF-05085727

PF-04885614 ≥98% (HPLC)

PZ0210

PF-04885614

PF-4778574 ≥98% (HPLC)

PZ0211

PF-4778574

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

solubility

DMSO: 0.5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

General description

10,11-Dihydro-10-hydroxycarbamazepine is a 10-hydroxy derivative and an active metabolite of oxcarbazepine.[1][2]
10,11-Dihydro-10-hydroxycarbamazepine is an active metabolite of the antiepileptic drug, oxcarbazepine.[3]

Application

10,11-Dihydro-10-hydroxycarbamazepine may be used as a reference standard in the determination of 10,11-dihydro-10-hydroxycarbamazepine in biological samples using liquid chromatography,[4] liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)[5] and high performance liquid chromatography coupled with ultraviolet detector (HPLC-UV).[6]
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Environment
GHS09

Hazard Statements

H411

Precautionary Statements

P273

Hazard Classifications

Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCC9313
    BCBT7305

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    Oxcarbazepine

    Johannes Pohl et al.
    Environmental science & technology, 54(5), 2913-2921 (2020-01-29)
    Carbamazepine (CBZ) is an anticonvulsant medication with highly persistent properties in the aquatic environment, where it has the potential to affect nontarget biota. Because CBZ and many other pharmaceuticals are not readily removed in conventional sewage treatment plants (STP), additional
    Anne-Catherine Servais et al.
    Journal of chromatography. A, 1467, 306-311 (2016-07-22)
    A LC method using a chiral stationary phase (CSP) with cellulose tris(3-chloro-4-methylphenylcarbamate) as chiral selector in polar organic mode (POM) was developed for the separation of the biopharmaceutic classification system (BCS) class II chiral prodrug eslicarbazepine acetate (ESL) and its
    Simultaneous quantitative analysis of oxcarbazepine and 10, 11-dihydro-10-hydroxycarbamazepine in human plasma by liquid chromatography-electrospray tandem mass spectrometry.
    Maia SdBM, et al.
    Journal of Pharmaceutical and Biomedical Analysis, 45(2), 304-311 (2007)
    Liquid chromatographic analysis of oxcarbazepine and its metabolites in plasma and saliva after a novel microextraction by packed sorbent procedure.
    Saracino M A, et al.
    Analytica Chimica Acta, 661(2), 222-228 (2010)
    Binding of licarbazepine enantiomers to mouse and human plasma proteins.
    Fortuna A, et al.
    Biopharmaceutics & Drug Disposition, 31(5-6), 362-366 (2010)
    View All Related Papers

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