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35837

Supelco

4-Aminophenol

PESTANAL®, analytical standard

Synonym(s):

4-Hydroxyaniline

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About This Item

Linear Formula:
H2NC6H4OH
CAS Number:
123-30-8
Molecular Weight:
109.13
Beilstein:
385836
EC Number:
204-616-2
MDL number:
MFCD00007869
UNSPSC Code:
41116107
PubChem Substance ID:
329755229

grade

analytical standard

Quality Level

100

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

185-189 °C (lit.)

solubility

water: slightly soluble

application(s)

agriculture
environmental

format

neat

SMILES string

Nc1ccc(O)cc1

InChI

1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2

InChI key

PLIKAWJENQZMHA-UHFFFAOYSA-N

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General description

4-Aminophenol can be obtained via the reduction of 4-nitrophenol with excess of sodium borohydride. It can also be obtained as a primary hydrolytic degradation product of paracetamol.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Skin Sens. 1 - STOT RE 2

Target Organs

Kidney

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ5817
BCCG9764
BCCF6308
BCCD8529
BCCB9332

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Mesalazine impurity A European Pharmacopoeia (EP) Reference Standard

Y0001563

Mesalazine impurity A

Paracetamol impurity K European Pharmacopoeia (EP) Reference Standard

Y0001955

Paracetamol impurity K

Acetaminophen analytical standard

Sigma-Aldrich

A3035

Acetaminophen

Reduction of 4-nitrophenol to 4-aminophenol over Au nanoparticles deposited on PMM
Kuroda K, et al.
J. Mol. Catal. A: Chem., 298, 7-11 (2009)
A sensitive and rapid assay for 4-aminophenol in paracetamol drug and tablet formulation, by flow injection analysis with spectrophotometric detection
Bloomfield.S.M
Talanta, 58, 1301-1310 (2002)
Y Xu et al.
Clinical chemistry, 36(11), 1941-1944 (1990-11-01)
A sandwich-type heterogeneous enzyme immunoassay with flow-injection analysis for alpha-fetoprotein (AFP) in human serum has been developed. 4-Aminophenol, the product of enzymatic reaction, is detected amperometrically. The interassay CV for this electrochemical enzyme immunoassay was less than 8.2%, with a
E P Gil et al.
Clinical chemistry, 36(4), 662-665 (1990-04-01)
A competitive enzyme-linked immunoabsorbent assay based on the flow-injection amperometric detection of p-aminophenol has been investigated with use of the materials and general procedure of a commercial kit for the determination of theophylline in human serum. The antibody is immobilized
Solomon Mehretie et al.
Talanta, 85(3), 1376-1382 (2011-08-03)
A sensitive and selective method was developed for the determination of N-acetyl-p-aminophenol (APAP) and p-aminophenol (PAP) using poly(3,4-ethylenedioxythiophene) (PEDOT)-modified glassy carbon electrode (GCE). Cyclic voltammetry and differential pulse voltammetry were used to investigate the electrochemical reaction of APAP and PAP
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