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CC065

Sigma-Aldrich

Human Tenascin-C Purified Protein

Synonym(s):

TN-C, Tenascin, Hexabrachion, Cytotactin, Neuronectin

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.75

biological source

human

Quality Level

100
300

Assay

>97% (SDS-PAGE)

form

liquid

mol wt

280—300 kDa

manufacturer/tradename

Chemicon®

concentration

0.1 mg/mL

technique(s)

cell culture | mammalian: suitable

input

sample type induced pluripotent stem cell(s)
sample type mesenchymal stem cell(s)
sample type neural stem cell(s)
sample type pancreatic stem cell(s)
sample type: human embryonic stem cell(s)
sample type epithelial cells
sample type hematopoietic stem cell(s)

solubility

water: soluble

NCBI accession no.

NM_002160.2

UniProt accession no.

P24821

Binding Specificity

Peptide Source: Fibrinogen

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... TNC(3371)

Related Categories

General description

Product Source: Human glioma cell line (U251).
Purified Human Tenascin-C Protien. Tenascin is known to: 1) play an active role in development of central nervous system and mesenchymal-derived organs; 2) exist in vasculature of tumors in adults; and 3) function in cell adhesion. By SDS-PAGE analysis, the protein migrates around 280-300kD.

Application

Cell adhesion assays.

Optimal working dilutions must be determined by end user.

Linkage

Replaces: CC066

Physical form

Purified protein supplied as a liquid in PBS containing no preservatives.

Storage and Stability

Maintain at -70ºC for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Minhua Yan et al.
Nephrology (Carlton, Vic.), 27(5), 458-466 (2022-02-26)
Tenascin-C (TNC), a non-structural extracellular matrix glycoprotein, is transiently expressed during development or after injury, playing an important role in injury and repair process. The potential role of TNC in the pathogenesis of IgA nephropathy (IgAN) remains to be clarified.
Cecelia C Yates et al.
Cell transplantation, 26(1), 103-113 (2016-07-28)
Mesenchymal stem cells (MSCs) remain of great interest in regenerative medicine because of their ability to home to sites of injury, differentiate into a variety of relevant lineages, and modulate inflammation and angiogenesis through paracrine activity. Many studies have found
Ting-Yu Huang et al.
BioMed research international, 2015, 712546-712546 (2015-04-04)
Urodele amphibians (Ambystoma mexicanum), unique among vertebrates, can regenerate appendages and other body parts entirely and functionally through a scar-free healing process. The wound epithelium covering the amputated or damaged site forms early and is essential for initiating the subsequent
Reza Mirzaei et al.
Oncoimmunology, 7(10), e1478647-e1478647 (2018-10-06)
The dismal prognosis of glioblastoma is attributed in part to the existence of stem-like brain tumor-initiating cells (BTICs) that are highly radio- and chemo-resistant. New approaches such as therapies that reprogram compromised immune cells against BTICs are needed. Effective immunotherapies
Bi Ning Zhang et al.
Journal of cellular physiology, 236(4), 2659-2668 (2020-09-02)
A postcataract surgery complication in patients with retinitis pigmentosa (RP) is lens capsular contraction. To identify potential proteins contributing to this phenomenon, high-performance liquid chromatography/mass spectrometry-based proteomic analysis was conducted with aqueous humor samples collected from 11 patients who underwent
View All Related Papers

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