06-1376

Anti-SLBP Antibody

serum, from rabbit

• Synonym(s): Histone stem-loop-binding protein, hairpin binding protein, histone binding protein 2, histone stem-loop binding protein, stem-loop (histone) binding protein, stem-loop binding protein, HBP, Histone RNA hairpin-binding protein
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: serum
• antibody product type: primary antibodies
• clone: polyclonal
• species reactivity: mouse, human
• species reactivity (predicted by homology): rat
• technique(s): immunocytochemistry: suitable; western blot: suitable
• NCBI accession no.: NM_009193
• UniProt accession no.: P97440
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... SLBP(7884)

Description

General description

The SLPB gene (stem-loop binding protein) encodes a protein that binds to the stem-loop structure of replication-dependent histone pre-mRNAs. Histone mRNA lack a polyadenylation signal. Consequently, the interaction of this protein with histone pre-mRNA contributes to efficient 3′ end processing by stabilizing the complex between the pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP). Expression of this protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1.

Specificity

Antibody recognizes SLBP.

Immunogen

KLH-conjugated linear peptide corresponding to the C-terminus of human SLBP.

Application

Immunocytochemistry:
Representative lot data.
Confocal fluorescent analysis of NIH/3T3 cells using 06-1376 (Red). Actin filaments have been labeled with AlexaFluor488 -Phalloidin (Green). Nucleus is stained with DAPI (Blue). This antibody positively stains cytoplasm and nucleus.

Research Sub Category
RNA Metabolism & Binding Proteins

Histones

Use Anti-SLBP Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect SLBP also known as Histone stem-loop-binding protein, HBP, Histone RNA hairpin-binding protein.

Quality

Evaluated by Western Blotting in C2C12 cell lysates.

Western Blotting Analysis: A 1:1000 dilution of this antibody detected SLBP in C2C12 cell lysates.

Target description

38 kDa

Physical form

Serum in buffer containing 0.05% sodium azide

Analysis Note

Control
C2C12 cell lysates.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1