860692P
Avanti
C16:0 Ceramide (d18:2(4E,8Z)/16:0)
Avanti Research™ - A Croda Brand 860692P, powder
Synonym(s):
N-palmitoyl-D-erythro-sphingosine (d18:2(4E,8Z) base)
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About This Item
Empirical Formula (Hill Notation):
C34H65NO3
CAS Number:
Molecular Weight:
535.88
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
form
powder
packaging
pkg of 1 × 1 mg (860692P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860692P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
OC[C@@](NC(CCCCCCCCCCCCCCC)=O)([H])[C@]([H])(O)/C=C/CC/C=C\CCCCCCCCC
General description
C16:0 Ceramide (d18:2(4E,8Z)/16:0) or N-palmitoyl-D-erythro-sphingosine (d18:2(4E,8Z) base) is a long chain ceramide derived from sphingosine containing two double bonds with palmitic acid. C16:0 Ceramide synthesis is catalyzed by the enzyme ceramide synthase 6 (CerS6).
Biochem/physiol Actions
C16:0-ceramide facilitates obesity-related insulin resistance. It exhibits pro-apoptotic function. Elevated levels of C16:0-ceramide has been observed in adipose tissue of obese patients.
Packaging
5 mL Amber Glass Screw Cap Vial (860692P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
No data available
Flash Point(C)
No data available
Certificates of Analysis (COA)
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Sarah M Turpin et al.
Cell metabolism, 20(4), 678-686 (2014-10-09)
Ceramides increase during obesity and promote insulin resistance. Ceramides vary in acyl-chain lengths from C14:0 to C30:0 and are synthesized by six ceramide synthase enzymes (CerS1-6). It remains unresolved whether obesity-associated alterations of specific CerSs and their defined acyl-chain length
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