Skip to Content
Merck
All Photos(1)

Key Documents

More Documents

699854P

Avanti

4A-MPLA (isomer C3)

Avanti Research™ - A Croda Brand

Synonym(s):

Monophosphopdyl Tetra-acyl Lipid A

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C68H132N3O19P
CAS Number:
2260669-09-6
Molecular Weight:
1326.76
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (HPLC)

form

powder

packaging

pkg of 1 × 1 mg (699854P-1mg)
pkg of 1 × 5 mg (699854P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

application(s)

vaccine development

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO)[C@@H](OP([O-])(O)=O)[C@@H]1O)O[C@H](O)[C@@H]2NC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H]2OC(C[C@H](O)CCCCCCCCCCC)=O.[NH4+]

Biochem/physiol Actions

Structural modification of diphosphoryl lipid A by hydrolysis produces MPLA (monophosphoryl lipid A) and is known to decrease its toxicity. MPLA, a lipopolysaccharide derivative, acts an immunomodulator and is non-toxic. For this reason, it is useful as a vaccine adjuvant. The MPLA induced immune response is tissue specific. It enhances host′s resistance against endotoxin induced effects. It also decreases cytokine production during infection.

Packaging

2 mL Amber Glass Crimp Cap Vial (699854P-1mg)
2 mL Amber Glass Crimp Cap Vial (699854P-5mg)

Other Notes

For R&D use only. Not for drug, household, or other uses.

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

The cytokine response to lipopolysaccharide does not predict the host response to infection
Fensterheim BA, et al.
Journal of immunology (Baltimore, Md. : 1950), 198(8), 3264-3273 (2017)
Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through a TLR4-TRIF-PI3K signaling pathway
Watts III BA, et al.
American Journal of Physiology: Renal Physiology, 313(1), F103-F115 (2017)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service