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O2256

Sigma-Aldrich

Oxolamine citrate salt

Synonym(s):

5-(2-[Diethylamino]ethyl)-3-phenyl-1,2,4-oxadiazole citrate salt, NSC 100298

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About This Item

Empirical Formula (Hill Notation):
C14H19N3O · C6H8O7
CAS Number:
1949-20-8
Molecular Weight:
437.44
EC Number:
217-760-6
MDL number:
MFCD00083457
UNSPSC Code:
12352100
PubChem Substance ID:
329818901
NACRES:
NA.22

Quality Level

200

storage temp.

2-8°C

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CC)CCc1nc(no1)-c2ccccc2

InChI

1S/C14H19N3O.C6H8O7/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-9H,3-4,10-11H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI key

RBZIGQJSMCOHSS-UHFFFAOYSA-N

Application

Molecule involved in pharmacological studies including:
  • Antiinflammatory agents
  • Drugs that shift energy metabolism from mitochondrial respiration to glycolysis
  • Effect on warfarin anticoagulant properties

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
080H0360

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[Therapeutic action of oxolamine in acute tracheo-bronchitis].
G Gunella et al.
La Clinica terapeutica, 100(5), 485-492 (1982-03-15)
L Kirilmaz et al.
Journal of microencapsulation, 9(2), 167-172 (1992-04-01)
One of the principal uses of microencapsulation for pharmaceuticals has been the preparation of sustained-release dosage forms which have been usually presented in the form of a suspension or gel. However, a non-disintegrating tablet would be a better formulation to
Xuan Zhu et al.
Biopharmaceutics & drug disposition, 28(3), 125-133 (2007-02-14)
The possible reason for the significantly greater AUC of oral warfarin with oral oxolamine in male Sprague-Dawley rats was evaluated. After oral administration of warfarin at a dose of 2 mg/kg to male rats with oxolamine at doses of 10
R Cerqua et al.
Minerva medica, 72(7), 355-362 (1981-02-28)
A single-blind, between-patients trial was run to compare the fluidifying, expectorant, antitussive, antipyretic and anti-inflammatory activity, and the local and systemic tolerance of guacetisal, an active principle obtained by the esterification of acetylsalicylic acid and guaiacol, and oxolamine phosphate, in
J McEwen et al.
The Medical journal of Australia, 150(8), 449-450 (1989-04-17)
Twenty reports in Australia, Belgium and The Netherlands have implicated oxolamine-citrate cough-mixtures as a cause of hallucinations in children of less than 10 years of age. Fever is not thought to be a likely alternative explanation. Similar reactions in older
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