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779229

Sigma-Aldrich

(2-Hydroxypropyl)-γ-cyclodextrin

Produced by Wacker Chemie AG, Burghausen, Germany, Life Science

Synonym(s):

Cavasol® W8 HP, HGC

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About This Item

CAS Number:
128446-34-4
UNSPSC Code:
12352201
NACRES:
NA.22

grade

Produced by Wacker Chemie AG, Burghausen, Germany, Life Science

Quality Level

200

form

powder

extent of labeling

0.5-0.7 molar substitution

impurities

≤0.1% propylene glycol (Ph Eur)

loss

≤10.0% loss on drying

pH

6-9 (2% in H2O)

InChI

1S/C51H88O38/c1-14(56)8-73-11-21-42-29(64)36(71)50(81-21)85-40-19(6-54)79-48(34(69)27(40)62)89-44-23(13-75-10-16(3)58)82-51(37(72)30(44)65)86-41-20(7-55)78-47(33(68)26(41)61)88-43-22(12-74-9-15(2)57)80-49(35(70)28(43)63)84-39-18(5-53)76-45(31(66)24(39)59)83-38-17(4-52)77-46(87-42)32(67)25(38)60/h14-72H,4-13H2,1-3H3/t14?,15?,16?,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1

InChI key

ODLHGICHYURWBS-RYJYQAAZSA-N

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General description

(2-Hydroxypropyl)-γ-cyclodextrin (HP-β-CD) is a hydrophilic compound that can be used as a complexing agent to increase the aqueous solubility and dissolution rate of the drug molecule.

Application

For R&D use
HP-β-CD can be utilized to improve the aqueous solubility and dissolution rate of zolpidem (ZP) upon complexation. ZP-HP-β-CD complexes showed improved ataxic activity.
It is also used to enhance the wound healing property of curcumin by increasing the water solubility.

Legal Information

Cavasol is a registered trademark of Wacker Chemie AG

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF9597
BCCF5137
BCCD9173
BCCD4716
BCCC7859

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Complexation of Zolpidem with 2-hydroxypropyl-β -, methyl-β -, and 2-hydroxypropyl-γ -cyclodextrin: Effect on aqueous solubility, dissolution rate, and ataxic activity in rat
Trapani, G, et al.
Journal of Pharmaceutical Sciences, 89(11), 1443-1451 (2000)
Physicochemical study and characterization of the trimethoprim/2-hydroxypropyl-γ -cyclodextrin inclusion complex
Macedo OFL, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 86(11), 101-106 (2012)
Enhancement of curcumin wound healing ability by complexation with 2-hydroxypropyl-γ-cyclodextrin in sacran hydrogel film
Wathoni N, et al.
International Journal of Biological Macromolecules, 98(11), 268-276 (2017)
Rachel J Smith et al.
The European journal of neuroscience, 30(3), 493-503 (2009-08-07)
The orexin/hypocretin system has recently been implicated in reward-processing and addiction. We examined the involvement of the orexin system in cue-induced reinstatement of extinguished cocaine-seeking by administering the orexin 1 receptor antagonist SB-334867 (SB) or the orexin 2 receptor antagonist
D E Rusyniak et al.
Neuroscience, 154(4), 1619-1626 (2008-06-07)
When given in a warm environment MDMA (3,4-methylenedioxymethamphetamine, ecstasy) causes hyperthermia by increasing interscapular brown adipose tissue (iBAT) heat production and decreasing heat loss via cutaneous vasoconstriction. When given in a cold environment, however, MDMA causes hypothermia by an unknown

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