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112291

Sigma-Aldrich

Ethyl salicylate

99%

Synonym(s):

Ethyl 2-hydroxybenzoate

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About This Item

Linear Formula:
2-(HO)C6H4CO2C2H5
CAS Number:
118-61-6
Molecular Weight:
166.17
Beilstein:
907659
EC Number:
204-265-5
MDL number:
MFCD00002215
UNSPSC Code:
12352100
eCl@ss:
39024568
PubChem Substance ID:
24847083
NACRES:
NA.22

vapor pressure

0.05 mmHg ( 25 °C)

Quality Level

100

Assay

99%

refractive index

n20/D 1.522 (lit.)

bp

234 °C (lit.)

mp

1 °C (lit.)

density

1.131 g/mL at 25 °C (lit.)

SMILES string

CCOC(=O)c1ccccc1O

InChI

1S/C9H10O3/c1-2-12-9(11)7-5-3-4-6-8(7)10/h3-6,10H,2H2,1H3

InChI key

GYCKQBWUSACYIF-UHFFFAOYSA-N

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General description

Ethyl salicylate was hydrolysed to salicylic acid by the use of an extractive electrospray ionisation (EESI) device.

Application

Ethyl salicylate is a non-steroidal analgesic, anti-inflammatory and antirrheumatic drug. Its complexation with β-cyclodextrin was studied using reversed-phase liquid chromatography.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

212.0 °F

Flash Point(C)

100 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A J Collins et al.
Annals of the rheumatic diseases, 43(3), 411-415 (1984-06-01)
A topically applied rubifacient delivered by aerosol (Deep-Heat) was studied. After spray application to the forearms of volunteers, without massage, the erythema produced was measured by thermography and correlated with the concentration of 2 salicylate components of the mixture found
Xiao-lan Chen et al.
Guang pu xue yu guang pu fen xi = Guang pu, 24(3), 379-380 (2005-03-12)
Atherton-Todd reaction has been extensively applied to the synthesis of phosphates and phosphoroamidates. Under Atherton-Todd reaction conditions, dialkyl phosphites were probably transformed into diakyl phosphorochloridates. We have tried to use Atherton-Todd reaction to synthesize phosphate of salicylic-acid. But when the
A Lapczynski et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 45 Suppl 1, S397-S401 (2007-11-21)
A toxicological and dermatological review of ethyl salicylate when used as a fragrance ingredient is presented.
Amnon C Sintov et al.
Journal of controlled release : official journal of the Controlled Release Society, 79(1-3), 113-122 (2002-02-21)
The aim of this study was to investigate the percutaneous penetration and dermal metabolism of a new potential anti-acne prodrug--TU-2100 [bis(o-carboxyphenyl ethyl ester)nonanedioate] in guinea pigs. The fluxes of this agent through excised skin after applications of TU-2100 gels at
Mauricio Filippa et al.
Journal of pharmaceutical and biomedical analysis, 48(3), 969-973 (2008-07-25)
The complexation of methyl salicylate (MS) and ethyl salicylate (ES), non-steroidal analgesic, anti-inflammatory and antirrheumatic drugs with beta-cyclodextrin (betaCD) has been studied from thermodynamic and structural points of view. The complexation with betaCD has been investigated using reversed-phase liquid chromatography.
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