105228

1,1,1,3,3,3-Hexafluoro-2-propanol

≥99%

• Synonym(s): HFP, Hexafluoroisopropanol
• Linear Formula: (CF₃)₂CHOH
• CAS Number: 920-66-1
• Molecular Weight: 168.04
• Beilstein: 1841007
• EC Number: 213-059-4
• MDL number: MFCD00011651
• UNSPSC Code: 12352104
• PubChem Substance ID: 24846695
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: ≥99%
• refractive index: n20/D 1.275 (lit.)
• bp: 59 °C (lit.)
• mp: −4 °C (lit.)
• density: 1.596 g/mL at 25 °C (lit.)
• SMILES string: OC(C(F)(F)F)C(F)(F)F
• InChI: 1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H
• InChI key: BYEAHWXPCBROCE-UHFFFAOYSA-N

Description

General description

1,1,1,3,3,3-Hexafluoro-2-propanol is a solution-phase peptide chemistry solvent. This fluorinated polar solvent of high ionizing power facilitates Friedel–Crafts-type reactions, using covalent reagents in the absence of a Lewis acid catalyst. It also enhances the efficiency of rhodium(I)-catalyzed [4+2] intramolecular cycloaddition of ether-tethered alkynyl dienes and [5+2] cycloaddition of alkynyl vinylcyclopropanes. 1,1,1,3,3,3-Hexafluoro-2-propanol clusters catalyzes the epoxidation of cyclooctene and 1-octene with hydrogen peroxide.

Application

1,1,1,3,3,3-Hexafluoro-2-propanol was used for preparing hexafluoroalcohol-functionalized methacrylate polymers for lithographic/nanopatterning materials.

Safety Information

• Pictograms: GHS08,GHS05
• Signal Word: Danger
• Hazard Statements: H314,H361fd,H373
• Precautionary Statements: P202 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Repr. 2 - Skin Corr. 1A - STOT RE 2 Oral
• Target Organs: Central nervous system
• Storage Class Code: 8B - Non-combustible corrosive hazardous materials
• WGK: WGK 2
• Flash Point(F): No data available
• Flash Point(C): No data available
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves