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SRP0159

Sigma-Aldrich

Histone H3 peptide (1-21) human

≥90% (HPLC)

Synonym(s):

HIST1H3E, Histone H3.1

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

Assay

≥90% (HPLC)

form

aqueous solution

mol wt

~2 kDa

packaging

pkg of 160 nmol

storage condition

avoid repeated freeze/thaw cycles

concentration

>0.02 mg/mL

NCBI accession no.

NM_003532

UniProt accession no.

P68431

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... HIST1H3E(8353)

Application

Study enzyme kinetics, and screen small molecular inhibitors of Histone 3, K4,K9, methyltransferases for drug discovery and HTS applications

Physical form

Supplied as water solution, 800 μM

Preparation Note

Thaw on ice. Upon first thaw, briefly spin tube to recover full content of the tube. Aliquot into single use aliquots. Store remaining product in aliquots at -70°C. Note: Avoid freeze/thaw cycles.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state.
Loyola A
Molecular Cell, 24(2), 309-316 (2006)
The differential mobilization of histones H3.1 and H3.3 by herpes simplex virus 1 relates histone dynamics to the assembly of viral chromatin.
Conn KL
PLoS Pathogens, 9(10), e1003695-e1003695 (2013)
Thomas H A Ederveen et al.
Biochimica et biophysica acta, 1809(10), 577-586 (2011-07-26)
Histones are highly basic, relatively small proteins that complex with DNA to form higher order structures that underlie chromosome topology. Of the four core histones H2A, H2B, H3 and H4, it is H3 that is most heavily modified at the
Hideaki Tagami et al.
Cell, 116(1), 51-61 (2004-01-14)
Deposition of the major histone H3 (H3.1) is coupled to DNA synthesis during DNA replication and possibly DNA repair, whereas histone variant H3.3 serves as the replacement variant for the DNA-synthesis-independent deposition pathway. To address how histones H3.1 and H3.3
The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly.
Ahmad K and Henikoff S
Molecular Cell, 9(6), 1191-1200 (2002)
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Articles

Histone Modification and Chromatin Remodeling | Epigenetics

Epigenetic modifications are thought to occur through two key interconnected processes—DNA methylation and the covalent modification of histones.

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