SML1652

RGFP966

≥98% (HPLC)

• Synonym(s): (2E)-N-(2-Amino-4-fluorophenyl)-3-[(2E)-1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide, (E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide, RGFP 966
• Empirical Formula (Hill Notation): C₂₁H₁₉FN₄O
• CAS Number: 1396841-57-8
• Molecular Weight: 362.40
• MDL number: MFCD26960954
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825992
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: NC1=CC(F)=CC=C1NC(/C=C/C(C=N2)=CN2C/C=C/C3=CC=CC=C3)=O
• InChI: 1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+
• InChI key: BLVQHYHDYFTPDV-VCABWLAWSA-N

Description

Biochem/physiol Actions

RGFP966 changes signal-specific primary auditory cortical plasticity. It is highly effective in cardiomyopathy-associated pathologies.

RGFP966 is a selective inhibitor of histone deacetylase 3 (HDAC3) with an IC₅₀ value of 80 nM and no inhibition of any other HDACs at concentrations up to 15 μM. In mouse studies, RGFP966 facilitated extinction of cocaine-seeking behavior and enhanced long-term object memory acquisition and consolidation. In a rat study, RGFP966 ameliorated amyloid-β oligomer-induced synaptic plasticity impairment. RGFP966 was also found to reduce proliferation and inducd differentiation in mouse lymphoid and myeloid malignancies.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3