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Key Documents

SAB4501665

Sigma-Aldrich

Anti-Keratin 18 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CK 18, CK18, CYK18, Cytokeratin endo B, K18

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 48 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P05783

UniProt accession no.

P05783

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KRT18(3875)

General description

Anti-Keratin 18 antibody detects endogenous levels of total Keratin 18 protein.
Keratin 18/cytokeratin 18 (CK18) is a structural protein. It is present in single-layer epithelia. It is located on human chromosome 12q13.

Immunogen

The antiserum was produced against synthesized peptide derived from human Keratin 18.

Immunogen Range: 381-430

Biochem/physiol Actions

Keratins help to maintain the structural integrity. They also control Fas‐mediated apoptosis and regulate cell size and protein synthesis. Keratin 18 plays a major role in the development of lung cancer. It acts as a therapeutic target for non-small cell lung cancer (NSCLC).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Diptendu Chatterjee et al.
European heart journal, 41(30), 2878-2890 (2020-06-14)
Brugada syndrome (BrS) is characterized by a unique electrocardiogram (ECG) pattern and life-threatening arrhythmias. However, the Type 1 Brugada ECG pattern is often transient, and a genetic cause is only identified in <25% of patients. We sought to identify an
Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13
Rogers MA, et al.
The Journal of Investigative Dermatology, 124(3), 536-544 (2005)
Spatiotemporal analysis of putative notochordal cell markers reveals CD24 and keratins 8, 18, and 19 as notochord-specific markers during early human intervertebral disc developmen
Rodrigues-Pinto R, et al.
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 34(8), 1327-1340 (2016)
Cytokeratin 18 knockdown decreases cell migration and increases chemosensitivity in non-small cell lung cancer
Zhang B, et al.
Journal of Cancer Research and Clinical Oncology, 142(12), 2479-2487 (2016)

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