SAB4300652

Anti-phospho-IGF-1R (pTyr¹²⁸⁰) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-CD221, Anti-IGFIR, Anti-IGFR
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 200-295 kDa
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (S-F-Yp-Y-S)
• NCBI accession no.: NM_000875.3
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr1280)
• Gene Information: human ... IGF-1R(3480)

Description

General description

The antibody detects endogenous levels of IGF-1R only when phosphorylated at tyrosine 1280.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 1280 (S-F-Yp-Y-S), according to the protein NP_000866.1

Features and Benefits

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Target description

This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. Ref.19 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, Ref.21 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable