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SAB4200807

Sigma-Aldrich

Anti-Superoxide Dismutase (SOD) antibody, Mouse monoclonal

clone SD-G6, purified from hybridoma cell culture

Synonym(s):

Cu-Zn, Superoxide dismutase 1, hSod1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

SD-G6, monoclonal

form

buffered aqueous solution

species reactivity

human, rat, canine

packaging

antibody small pack of 25 μL

technique(s)

indirect ELISA: 0.3-0.6 μg/mL using 5μg/ml Superoxide Dismutase from human erythrocytes for coating

isotype

IgG1

UniProt accession no.

P00441

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SOD1(6647)

Related Categories

General description

Superoxide Dismutase (SOD) is a family of metalloenzymes widely distributed in both plants and animals. Superoxide dismutases appear to protect cells against reactive free radicals by scavenging the superoxide radicals produced by ionization radiation or through other mechanisms. SOD enzyme catalyzes the conversion of single electron reduced species of molecular oxygen to hydrogen peroxide and oxygen. There are several classes of SOD that differ in their metal binding ability, distribution in different cell compartments, and sensitivity to various reagents. Among these, Cu, Zn superoxide dismutase (SOD1) is widely distributed and comprises 90% of the total SOD. This ubiquitous enzyme, which requires Cu and Zn for its activity, has great physiological significance and therapeutic potential.

Immunogen

recombinant human copper-zinc superoxide dismutase (Cu-Zn-SOD).

Application

Monoclonal Anti-Superoxide Dismutase (SOD) recognizes natural (human erythrocyte SOD), recombinant SOD (human Cu-Zn-SOD and human placental SOD) and the enzymatically inactive form of these enzymes. Reactivity has been observed with SOD from human, rat and dog origin, no reactivity was observed with SOD from bovine, bacillus stearothermophilus or E. coli (Fe or Mn) origin. The antibody is recommended to use in various immunological techniques, including ELISA, Immunohistochemistry and immunofluorescence.

Physical form

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

Other Notes

This product is for R&D use only, not for drug, household, or other uses.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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H D Durham et al.
Journal of neuropathology and experimental neurology, 56(5), 523-530 (1997-05-01)
Mutations in the Cu/Zn-superoxide dismutase (SOD-1) gene underlie some familial cases of amyotrophic lateral sclerosis (FALS), a neurodegenerative disorder characterized by loss of cortical, brainstem, and spinal motor neurons. To investigate the mechanisms responsible for the toxicity of mutant enzyme
Rana Noor et al.
Medical science monitor : international medical journal of experimental and clinical research, 8(9), RA210-RA215 (2002-09-10)
Reactive oxygen species, such as superoxide radicals, are thought to underlie the pathogenesis of various diseases. Almost 3 to 10% of the oxygen utilized by tissues is converted to its reactive intermediates, which impair the functioning of cells and tissues.
Delira Robbins et al.
Antioxidants & redox signaling, 20(10), 1628-1645 (2013-05-28)
Cancer is the second leading cause of death in the United States. Considering the quality of life and treatment cost, the best way to fight against cancer is to prevent or suppress cancer development. Cancer is preventable as indicated by
J Muchová et al.
Physiological research, 63(5), 535-542 (2014-06-09)
Oxidative stress is a phenomenon associated with imbalance between production of free radicals and reactive metabolites (e.g. superoxide and hydrogen peroxide) and the antioxidant defences. Oxidative stress in individuals with Down syndrome (DS) has been associated with trisomy of the

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