P2745
Protein Phosphatase Inhibitor 1 human
Synonym(s):
Inhibitor 1 human
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Recommended Products
biological source
human
Quality Level
recombinant
expressed in E. coli
Assay
>95% (SDS-PAGE)
form
solution
mol wt
~31 kDa
apparent mol wt ~27 kDa
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PPP1R1A(5502) , PPP1R8(5511)
Looking for similar products? Visit Product Comparison Guide
Application
This protein phosphatase inhibitor 1 is suitable for use as a substrate to identify novel phosphatases and kinases that modulate protein phosphatase inhibitor 1 activity. This product is also suitable for use in affinity pull-down binding studies. Protein Phosphatase Inhibitor 1 human has been used as a component in the sucrose cell lysis buffer. It has also been used for intraperitoneal injection of mice prior to natterins or saline treatment in pharmacological intervention studies.
Biochem/physiol Actions
Intimately involved in glycogen metabolism as an inhibitor of phosphorylase phosphatase, the enzyme responsible for conversion of phosphorylase b to phosphorylase a. Inhibition is invoked only upon phosphorylation by a cAMP-dependent protein kinase.
Physical form
Supplied as a solution in 50 mM Tris-HCl, pH 7.0, containing 0.1 mM PMSF, 14 mM 2-mercaptoethanol, and 10% glycerol
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Skin Sens. 1
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Inhibition of Inflammatory Changes in Human Myometrial Cells by Cell Penetrating Peptide and Small Molecule Inhibitors of NF kappaB
Gurney LRI, et al.
Frontiers in Immunology, 9, 2966-2966 (2018)
Zlatka Plavec et al.
Viruses, 14(9) (2022-09-24)
Severe acute respiratory syndrome coronavirus-2 is the causative agent of COVID-19. During the pandemic of 2019-2022, at least 500 million have been infected and over 6.3 million people have died from COVID-19. The virus is pleomorphic, and due to its
Furong Song et al.
International journal of molecular medicine, 46(3), 1135-1145 (2020-07-25)
Propofol is a commonly used drug for the induction and maintenance of anesthesia. Previous studies have reported that propofol is involved in the progression of numerous human cancer types, including hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms in HCC
Xiaonan Liu et al.
Molecular systems biology, 17(11), e10396-e10396 (2021-10-29)
Treatment options for COVID-19, caused by SARS-CoV-2, remain limited. Understanding viral pathogenesis at the molecular level is critical to develop effective therapy. Some recent studies have explored SARS-CoV-2-host interactomes and provided great resources for understanding viral replication. However, host proteins
Marcio Jose Ferreira et al.
Toxicon : official journal of the International Society on Toxinology, 87, 54-67 (2014-06-03)
Here we evaluated whether Natterins affect the leukocyte-endothelial cell interaction, hampering leukocyte mobilization and extravasation. Leukocyte-endothelial cell interactions were evaluated in venules of mouse cremaster muscle using intravital microscopy. We reported that low doses of Natterins interfere with the cell
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service