N6754

α-Nicotinamide adenine dinucleotide

from Saccharomyces cerevisiae, ≤1% β-isomer, ≥95%

• Synonym(s): α-DPN, α-Diphosphopyridine nucleotide, α-NAD
• Empirical Formula (Hill Notation): C₂₁H₂₇N₇O₁₄P₂
• CAS Number: 7298-93-3
• Molecular Weight: 663.43
• EC Number: 230-738-0
• MDL number: MFCD00134828
• UNSPSC Code: 41106305
• PubChem Substance ID: 24897790
• NACRES: NA.51

Properties

• biological source: Saccharomyces cerevisiae
• Quality Level: 200
• Assay: ≥95%
• form: powder
• impurities: ≤1% β-isomer
• solubility: H₂O: soluble-50 mg/mL, clear, colorless to faintly yellow
• storage temp.: −20°C
• SMILES string: NC(=O)c1ccc[n+](c1)[C@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O
• InChI: 1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20+,21-/m1/s1
• InChI key: BAWFJGJZGIEFAR-OPDHFMQKSA-N

Description

General description

Nicotinamide adenine dinucleotide (NAD) is an important cofactor for oxidation-reduction reactions in mitochondria.

Application

α-Nicotinamide adenine dinucleotide (αNAD) may be used together with other NAD analogues to study the specificity and kinetics of NAD-dependent and NAD-transporting enzymes and proteins, such as NAD-glycohydrolase(s) and the mitochondrial NAD+ transporter in Saccharomyces cerevisiae.

α-Nicotinamide adenine dinucleotide has been used in superoxide dismutase activity of seminal plasma samples and in glutathione peroxidase assay of liver, kidney, testes and brain samples.

Biochem/physiol Actions

α-Nicotinamide adenine dinucleotide (α-NAD) is a substrate for renalase. α-NAD, an analog of β-NAD, when used modulates kinetics of NAD dependent enzymes.

Other Notes

α analog of β-NAD

Caution

This is not the common NAD required in the usual enzyme systems.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves