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LO1280

Sigma-Aldrich

LOPAC®1280

Synonym(s):

Library of Pharmacologically Active Compounds

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About This Item

UNSPSC Code:
12352202

form

liquid

shipped in

dry ice

storage temp.

−20°C

General description

Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (250 μl at 10 mM in DMSO).

Application

LOPAC®1280 has been used:
  • in the screening of novel inhibitors for chemotaxis/ migration using Dictyostelium as a model
  • to test the ability to modulate and to measure forskolin-stimulated cAMP levels in CHO-hCB2 cells and to modulate ligand-induced receptor/β-arrestin interaction
  • in screening of small molecules for activating bone morphogenetic protein (BMP) signaling
  • in screening of compounds that plays a role in regulating subcellular localization of nitric oxide associated protein 1 (NOA1) protein

Features and Benefits

Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:

  • Apoptosis
  • G Proteins & Cyclic Nucleotides
  • Gene Regulation & Expression
  • Ion Channels
  • Lipid Signaling
  • Multi-Drug Resistance
  • Neurotransmission
  • Phosphorylation
SDFile provided to construct a database containing:
  • Structure
  • Primary Name
  • Secondary Name
  • Pharmacological Activity
  • Product Number
  • Rack Position
Collection of 1,280 Pharmacologically-Active Sigma Compounds
To request a list of components, please visit sigma.com/LOPAC

Other Notes

For sale in the U.S. only. Customers outside of the U.S. should refer to product code LO3300.

Legal Information

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Flash Point(F)

188.6 °F - closed cup

Flash Point(C)

87 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Karen Camargo-Sosa et al.
PLoS genetics, 15(2), e1007941-e1007941 (2019-02-28)
Skin pigment patterns are important, being under strong selection for multiple roles including camouflage and UV protection. Pigment cells underlying these patterns form from adult pigment stem cells (APSCs). In zebrafish, APSCs derive from embryonic neural crest cells, but sit
NOA1, a novel ClpXP substrate, takes an unexpected nuclear detour prior to mitochondrial import
Al-Furoukh N, et al.
PLoS ONE, 9(7), e103141-e103141 (2014)
Identification of small molecule activators of BMP signaling
Vrijens K, et al.
PLoS ONE, 8(3), e59045-e59045 (2013)
A Unique High-Throughput Assay to Identify Novel Small Molecule Inhibitors of Chemotaxis and Migration
Liao XH and Kimmel AR
Current Protocols in Cell Biology, 74(1), 12-11 (2017)
Clara Lettl et al.
Frontiers in cellular and infection microbiology, 10, 602958-602958 (2021-01-05)
Type IV secretion systems are protein secretion machineries that are frequently used by pathogenic bacteria to inject their virulence factors into target cells of their respective hosts. In the case of the human gastric pathogen Helicobacter pylori, the cytotoxin-associated gene
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