GW21470
Anti-PPFIA1 (ab1) antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-LAR-interacting protein 1, Anti-LIP.1, Anti-LIP1, Anti-LIPA1_HUMAN, Anti-LIPRIN, Anti-Liprin-α-1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
chicken
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, mouse, human
manufacturer/tradename
Genway 15-288-21470
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PPFIA1(8500)
Immunogen
Immunogen Sequence: GI # 4505983, sequence 310-360
Recombinant PTPRF interacting protein α 1 isoform b
Application
Anti-PPFIA1 (ab1) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Liprin-α-1 is a cytoplasmic 160kDa phosphoserine protein encoded by the PPFIA1 gene in humans. It encodes liprin α, a protein involved in cell adhesion, integrin expression and cell-matrix interactions. PPFIA1 may act as a potential functional candidate for acute lung injury risk gene for future research. It is frequently co-amplified with the Cyclin D1 gene in oral carcinomas and may present a biomarker as well as a novel target for specific gene therapy. Liprin′s function is to localize LAR family tyrosine phosphatases at specific sites on the plasma membrane. It may help in regulating their interaction with the extracellular environment and their associations with substrates. PPFIA1 may regulate the disassembly of focal adhesions and help to orchestrate cell-matrix interactions.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Marco Blessmann et al.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 41(8), 845-849 (2013-03-05)
Analyzing chromosomal amplifications delivers valuable information for identification of oncogenes. For carcinomas of the oral cavity only few genes have been identified in amplified regions. The aim of this study was to search genes in amplified regions as possible biomarkers
Jason D Christie et al.
PloS one, 7(1), e28268-e28268 (2012-02-02)
Acute Lung Injury (ALI) is a syndrome with high associated mortality characterized by severe hypoxemia and pulmonary infiltrates in patients with critical illness. We conducted the first investigation to use the genome wide association (GWA) approach to identify putative risk
C Serra-Pagès et al.
The EMBO journal, 14(12), 2827-2838 (1995-06-15)
Focal adhesions are sites of cell-extracellular matrix interactions that function in anchoring stress fibers to the plasma membrane and in adhesion-mediated signal transduction. Both focal adhesion structure and signaling ability involve protein tyrosine phosphorylation. LAR is a broadly expressed transmembrane
C Serra-Pagès et al.
The Journal of biological chemistry, 273(25), 15611-15620 (1998-06-23)
LAR family transmembrane protein-tyrosine phosphatases function in axon guidance and mammary gland development. In cultured cells, LAR binds to the intracellular, coiled coil LAR-interacting protein at discrete ends of focal adhesions, implicating these proteins in the regulation of cell-matrix interactions.
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