C127
CNQX
≥98% (HPLC), solid
Synonym(s):
6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065
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About This Item
Empirical Formula (Hill Notation):
C9H4N4O4
CAS Number:
Molecular Weight:
232.15
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Quality Level
Assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
yellow
solubility
DMSO: >10 mg/mL
H2O: insoluble
SMILES string
[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N
InChI
1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
InChI key
RPXVIAFEQBNEAX-UHFFFAOYSA-N
Gene Information
rat ... Gria1(50592) , Grik1(29559) , Grik2(54257) , Grik4(24406) , Grin2a(24409)
Application
CNQX has been used:
- as an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate blocker to study its effects on cytoneme formation in pluripotent embryonic stem cells (pESCs)
- glutamate blocker to reduce the synaptic input during current-clamp recordings in central antennal lobe neurons
- as a non-N-methyl-D-aspartate (NMDA) receptor blocker to study its effects on the heart rate in rats
Biochem/physiol Actions
Potent, competitive AMPA/kainate glutamate receptor antagonist.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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