79849
(±)-Mevalonic acid 5-phosphate lithium salt hydrate
95% (TLC)
Synonym(s):
(±)-MVAP-Li, rac-5-Phosphomevalonate lithium salt
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About This Item
Empirical Formula (Hill Notation):
C6H13O7P · xLi+ · yH2O
Molecular Weight:
228.14 (free acid basis)
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
Recommended Products
Quality Level
Assay
95% (TLC)
form
powder or crystals
relevant disease(s)
Alzheimer′s disease; autoimmune diseases
storage temp.
2-8°C
SMILES string
OC(CC(C)(O)CCOP(O)(O)=O)=O.[H]O[H].[Li+]
InChI
1S/C6H13O7P.3Li.H2O/c1-6(9,4-5(7)8)2-3-13-14(10,11)12;;;;/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12);;;;1H2/q;3*+1;/p-3
InChI key
VYTYNAKRCDFACM-UHFFFAOYSA-K
Related Categories
Biochem/physiol Actions
Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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D N Skilleter et al.
The Biochemical journal, 124(2), 407-417 (1971-09-01)
1. Phosphomevalonate kinase and 5-pyrophosphomevalonate decarboxylase have been purified from the freeze-dried latex serum of the commercial rubber tree Hevea brasiliensis. 2. The phosphomevalonate kinase was acid- and heat-labile and required the presence of a thiol to maintain activity. 3.
Inhibition of hepatic cholesterol biosynthesis by 3,5-dihydroxy-3,4,4-trimethylvaleric acid and its site of action.
F H Hulcher
Archives of biochemistry and biophysics, 146(2), 422-427 (1971-10-01)
John L Andreassi et al.
Biochemistry, 48(27), 6461-6468 (2009-06-03)
The galacto-, homoserine-, mevalonate-, phosphomevalonate-kinase (GHMP) superfamily encompases a wide-range of protein function. Three members of the family (mevalonate kinase, phosphomevalonate kinase, and diphosphomevalonate decarboxylase) comprise the mevalonate pathway found in S. pneumoniae and other organisms. We have determined the
Andrew L Olson et al.
Journal of the American Chemical Society, 132(7), 2102-2103 (2010-02-02)
Phosphomevalonate kinase (PMK) catalyzes phosphoryl transfer from adenosine triphosphate (ATP) to mevalonate 5-phosphate (M5P) on the pathway for synthesizing cholesterol and other isoprenoids. To permit this reaction, its substrates must be brought proximal, which would result in a significant and
Andrew L Olson et al.
Proteins, 75(1), 127-138 (2008-09-19)
Phosphomevalonate kinase (PMK) catalyzes an essential step in the mevalonate pathway, which is the only pathway for synthesis of isoprenoids and steroids in humans. PMK catalyzes transfer of the gamma-phosphate of ATP to mevalonate 5-phosphate (M5P) to form mevalonate 5-diphosphate.
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