299537

Trifluoroacetic acid

≥99%, for protein sequencing

• Synonym(s): TFA
• Linear Formula: CF₃COOH
• CAS Number: 76-05-1
• Molecular Weight: 114.02
• Beilstein: 742035
• EC Number: 200-929-3
• MDL number: MFCD00004169
• UNSPSC Code: 12352106
• PubChem Substance ID: 329753402
• NACRES: NA.21

Properties

• vapor density: 3.9 (vs air)
• Quality Level: 100
• vapor pressure: 97.5 mmHg ( 20 °C)
• type: for protein sequencing
• Assay: ≥99%
• form: liquid
• impurities: <0.05% water
• evapn. residue: <0.005%
• refractive index: n20/D 1.3 (lit.)
• pH: 1 (20 °C, 10 g/L)
• bp: 72.4 °C (lit.)
• mp: −15.4 °C (lit.)
• density: 1.489 g/mL at 20 °C (lit.)
• SMILES string: OC(C(F)(F)F)=O
• InChI: 1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)
• InChI key: DTQVDTLACAAQTR-UHFFFAOYSA-N

Description

General description

Trifluoroacetic acid is a naturally occurring organic solvent and biodegradable by microbial action. It can also be used as a catalyst for various organic transformations, including solvolysis, rearrangements, reductions, oxidations, and trifluoromethylation.

Application

Trifluoroacetic acid can be used as a solvent in the:

• Mass spectrometry for protein identification.
• Microwave-irradiated bromination of isoxazoles and pyrazoles with N-bromosuccinimide to synthesize mono-brominated isoxazoles and pyrazoles.
• Lewis acid-catalyzed 6-endo-digcyclization of 2-(2-arylethynyl)heteroaryl esters to heterocyclic lactones.
• Electrospinning of cellulose acetate to prepare the corresponding nanofibrous membranes.

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H314 - H332 - H412
• Precautionary Statements: P261 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
• Storage Class Code: 8A - Combustible, corrosive hazardous materials
• WGK: WGK 2
• Flash Point(F): No data available
• Flash Point(C): No data available