T6399

Trichloroacetic acid

ACS reagent, ≥99.0%

• Synonym(s): TCA
• Linear Formula: Cl₃CCOOH
• CAS Number: 76-03-9
• Molecular Weight: 163.39
• Beilstein: 970119
• EC Number: 200-927-2
• MDL number: MFCD00004177
• UNSPSC Code: 12352100
• PubChem Substance ID: 24900373
• NACRES: NA.21

Properties

• grade: ACS reagent
• Quality Level: 200
• vapor density: <1 (vs air)
• vapor pressure: 1 mmHg ( 51 °C)
• Assay: ≥99.0%
• impurities: Substances darkened by sulfuric acid, passes test; ≤0.01% insoluble matter
• ign. residue: ≤0.03%
• refractive index: n20/D 1.62 (lit.)
• bp: 196 °C (lit.)
• mp: 54-58 °C (lit.)
• solubility: H₂O: 1 g/10 mL
• density: 1.62 g/mL at 25 °C (lit.)
• anion traces: chloride (Cl^-): ≤0.002%; nitrate (NO₃^-): ≤0.002%; phosphate (PO₄^3-): ≤5 ppm; sulfate (SO₄^2-): ≤0.02%
• cation traces: Fe: ≤0.001%; heavy metals (as Pb): ≤0.002%
• functional group: carboxylic acid; chloro
• storage temp.: 2-8°C
• SMILES string: OC(=O)C(Cl)(Cl)Cl
• InChI: 1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)
• InChI key: YNJBWRMUSHSURL-UHFFFAOYSA-N

Description

Application

• Trichloroacetic acid has been used for the precipitation of sLRP (soluble circulating low density lipoprotein receptor-related protein-1) isolated from plasma.
• It has been used for the extraction of ascorbic acid from plant samples. It has also been used for the preparation of ascorbate standards for ascorbate assay.
• It has been used for the precipitation of IMAC (immobilized metal ion affinity chromatography)-isolated phosphoproteins.

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.

Safety Information

• Pictograms: GHS05,GHS09
• Signal Word: Danger
• Hazard Statements: H314,H410
• Precautionary Statements: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A
• Storage Class Code: 8B - Non-combustible corrosive hazardous materials
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves