PHL89262

Quercetin

phyproof^® Reference Substance

• Synonym(s): 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 3,3′,4′,5,6-Pentahydroxyflavone
• Empirical Formula (Hill Notation): C₁₅H₁₀O₇
• CAS Number: 117-39-5
• Molecular Weight: 302.24
• Beilstein: 317313
• UNSPSC Code: 41116107

Properties

• grade: primary reference standard
• product line: phyproof^® Reference Substance
• Assay: ≥95.0% (HPLC)
• manufacturer/tradename: PhytoLab
• application(s): food and beverages
• format: neat
• SMILES string: OC1=CC(O)=C2C(OC(C3=CC=C(O)C(O)=C3)=C(O)C2=O)=C1
• InChI: 1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
• InChI key: REFJWTPEDVJJIY-UHFFFAOYSA-N

Description

General description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Application

• Simultaneous determination of eight arginine-related metabolites in cellular extracts using liquid chromatography-tandem mass spectrometry.: This study utilized the Chromolith^® RP-18 endcapped column to achieve high-resolution separation of arginine-related metabolites in cellular extracts. The method demonstrated excellent reproducibility and sensitivity, highlighting the column′s effectiveness in complex biological sample analysis (Amatya S et al., 2020).


• Rapid Determination of 30 Polyphenols in Tongmai Formula, a Combination of Puerariae Lobatae Radix, Salviae Miltiorrhizae Radix et Rhizoma, and Chuanxiong Rhizoma, via Liquid Chromatography-Tandem Mass Spectrometry.: The Chromolith^® RP-18 endcapped column was employed for the rapid and efficient determination of polyphenols in a traditional Chinese medicine formula. The column′s high throughput and robust performance facilitated the simultaneous analysis of multiple compounds, demonstrating its application in natural product research (Wang FR et al., 2017).


• Simultaneous Liquid Chromatographic Determination of Ebastine with Two Sympathomimetic Drugs Using a Monolithic Column.: This research applied the Chromolith^® RP-18 endcapped column to the simultaneous chromatographic determination of ebastine and two sympathomimetic drugs. The study underscored the column′s ability to provide rapid and efficient separations in pharmaceutical analysis, ensuring accurate quantification of drug components (Ibrahim F et al., 2017).

Biochem/physiol Actions

Quercetin is a flavonoid with anticancer activity. Quercetin is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle. Quercetin may also inhibit fatty acid synthase activity.

Legal Information

Chromolith is a registered trademark of Merck KGaA, Darmstadt, Germany

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3