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M9546

Sigma-Aldrich

D-Mannitol

BioXtra, ≥98% (HPLC)

Synonym(s):

Mannite

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About This Item

Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
Molecular Weight:
182.17
Beilstein:
1721898
EC Number:
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.21

product line

BioXtra

Quality Level

Assay

≥98% (HPLC)

form

powder

impurities

≤0.0005% Phosphorus (P)
≤0.01% Insoluble matter

ign. residue

≤0.01%

color

white

useful pH range

5.0-6.5 (25 °C, 182 g/L)

mp

167-170 °C (lit.)

solubility

H2O: 1 M, clear, colorless

anion traces

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

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General description

D-Mannitol is the alcohol form of mannose. Its molar mass is 182 g/mol. Mannitol is present widely in plants, fungi and algae. It is extracted mainly from seaweeds. It is used in food for diabetic patients as it is absorbed slowly. It is commonly used as a stabilizer, humectant, nutritive sweetener and bulking agent in food.

Application

D-Mannitol has been used:
  • as a hydroxyl radical inhibitor, to detect the hydroxyl radical generation during the reactive oxygen species (ROS) modification of chromatin
  • in [3H]-mannitol permeability assay and also as a component in buffer B for measuring the transmonolayer dilution potentials
  • as a component in extracellular recording solution for whole cell patch clamp recordings

Biochem/physiol Actions

D-Mannitol is used as an osmotic agent for the treatment of brain swellings.
A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

Other Notes

To gain a comprehensive understanding of our extensive range of Sugar alcohols for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Sweeteners: Nutritional Aspects, Applications, and Production Technology, 59-59 (2012)
Methods to examine tight junction physiology in cancer stem cells: TEER, paracellular permeability, and dilution potential measurements
Buchert M, et al.
Stem Cell Reviews and Reports, 8(3), 1030-1034 (2012)
Neurology of the Newborn, 459-459 (2008)
Allosteric interactions between NMDA receptor subunits shape the developmental shift in channel properties
Sun W, et al.
Neuron, 94(1), 58-64 (2017)
Antibodies against 4-hydroxy-2-nonenal modified epitopes recognized chromatin and its oxidized forms: role of chromatin, oxidized forms of chromatin and 4-hydroxy-2-nonenal modified epitopes in the etiopathogenesis of SLE
Al-Shobaili HA, et al.
Disease Markers, 33(1), 19-34 (2012)

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