ABN462
Anti-Dopamine D2 Receptor Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
Dopamine D2 Receptor, D2R
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse
technique(s)
immunohistochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
mouse ... Drd2(13489)
General description
The Dopamine D2 Receptor is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. 2 isoforms are reported for the D2 Dopamine Receptor, Isoform 1 and isoform 2 which are expressed in the pituitary and brain; Isoform 1 is expressed seven times more than isoform 2 in the caudate nucleus.
Specificity
This antibody binds to the cytoplasmic third intracellular loop.
Immunogen
Epitope: cytoplasmic third intracellular loop
Recombinant protein corresponding to the cytoplasmic domain of mouse Dopamine D2 Receptor.
Application
Anti-Dopamine D2 Receptor Antibody is an antibody against Dopamine D2 Receptor for use in Immunohistochemistry.
Immunohistochemistry Analysis: A representative lot detected Dopamine D2 Receptor in WT mouse striatum tissue (Trifilieff, P., et al. (2013). Molecular Psychiatry. 18:102-1033).
Immunohistochemistry Analysis: A representative lot detected Dopamine D2 Receptor in wild-type and not in D2R knockout mouse sriatum tissue (Trifilieff, P., et al. (2011). BioTechniques. 50:111-118).
Immunohistochemistry Analysis: A representative lot detected Dopamine D2 Receptor in wild-type and not in D2R knockout mouse sriatum tissue (Trifilieff, P., et al. (2011). BioTechniques. 50:111-118).
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
Quality
Evaluated by Immunohistochemistry in mouse striatum tissue.
Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Dopamine D2 Receptor in mouse striatum tissue.
Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Dopamine D2 Receptor in mouse striatum tissue.
Target description
50.9 kDa calculated
Physical form
Affinity
Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation.
Trifilieff, P; Feng, B; Urizar, E; Winiger, V; Ward, RD; Taylor, KM; Martinez, D; Moore et al.
Molecular Psychiatry null
Ying Zhu et al.
BioTechniques, 68(3), 122-129 (2019-12-21)
Despite the controversy regarding the existence and physiological relevance of class A G protein-coupled receptor dimerization, there is substantial evidence for functional interactions between the dopamine D2 receptor (D2R) and the adenosine A2A receptor (A2AR). A2AR-D2R complexes have been detected in
Pierre Trifilieff et al.
BioTechniques, 51(2), 111-118 (2011-08-03)
The existence of G protein-coupled receptor (GPCR) dimers and/or oligomers has been demonstrated in heterologous systems using a variety of biochemical and biophysical assays. While these interactions are the subject of intense research because of their potential role in modulating
Benjamin Lassus et al.
Scientific reports, 8(1), 17461-17461 (2018-12-01)
Although the prefrontal cortex and basal ganglia are functionally interconnected by parallel loops, cellular substrates underlying their interaction remain poorly understood. One novel approach for addressing this issue is microfluidics, a methodology which recapitulates several intrinsic and synaptic properties of
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