AB3036
Anti-Uncoupling Protein 1 Antibody
Chemicon®, from rabbit
Synonym(s):
UCP1
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
mouse ... Ucp1(22227)
Specificity
Uncoupling Protein 1 (UCP1), mouse. Mouse/rat UCP1 is a 307 amino acid mitochondrial uncoupling protein (Bouillaud et al. 1986; Ridley et al. 1986; Kozak et al. 1988; Cassard et al. 1990; Miroux et al. 1993). It is only 59% homologous with UCP2 (Fleury et al. 1997). Human UCP1 is located on chromosome 4 (Bouillaud et al. 1986; Ridley et al. 1986; Kozak et al. 1988; Cassard et al. 1990; Miroux et al. 1993). UCP1 is primarily expressed in brown adipose tissues.
The antibody has not yet been tested for cross-reactivity to other species. The sequence used for immunization shows 100% homology to rat, 91% with golden hamster, 83% with rabbit and 75% with human and canine UCP1.
The antibody has not yet been tested for cross-reactivity to other species. The sequence used for immunization shows 100% homology to rat, 91% with golden hamster, 83% with rabbit and 75% with human and canine UCP1.
Immunogen
A 12 aa peptide at the C-terminus of the mouse/rat UCP1 (Bouillaud et al. 1986; Ridley et al. 1986; Kozak et al. 1988; Cassard et al. 1990; Miroux et al. 1993).
Application
Detect Uncoupling Protein 1 using this Anti-Uncoupling Protein 1 Antibody validated for use in ELISA & WB.
Western Blotting: 1-10 μg/mL using Chemiluminescence technique. An antibody made to this epitope has detected a protein of ~32 kDa in brown adipose tissues (Feil & Rafael 1994).
ELISA: 1:10,000-1:100,000; using 50-100 ng UCP1 control peptide/well.
Optimal working dilutions must be determined by end user.
ELISA: 1:10,000-1:100,000; using 50-100 ng UCP1 control peptide/well.
Optimal working dilutions must be determined by end user.
Physical form
Affinity purified immunoglobulin. Liquid in PBS with less than 0.1% sodium azide.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Jing Luo et al.
Frontiers in endocrinology, 13, 877152-877152 (2022-05-21)
Thermogenic adipocytes possess a promising approach to combat obesity with its capability promoting energy metabolism. We previously discovered that deletion of GPR30 (GPRKO), a presumably membrane-associated estrogen receptor, protected female mice from developing obesity, glucose intolerance, and insulin resistance when
EID1-induces brown-like adipocyte traits in white 3T3-L1 pre-adipocytes.
Fernando Lizcano,Diana Vargas
Biochemical and biophysical research communications null
Andrea V Rozo et al.
Molecular metabolism, 6(7), 748-759 (2017-07-14)
Adult obesity risk is influenced by alterations to fetal and neonatal environments. Modifying neonatal gut or neurohormone signaling pathways can have negative metabolic consequences in adulthood. Here we characterize the effect of neonatal activation of glucagon like peptide-1 (GLP-1) receptor
B Miroux et al.
The EMBO journal, 12(10), 3739-3745 (1993-10-01)
The uncoupling protein (UCP) of brown adipose tissue mitochondria is a specialized member of the family of evolutionarily related mitochondrial membrane transporters, which also includes the ADP/ATP translocator and the phosphate carrier. We have generated a library of bacterial clones
Melanie Lacaria et al.
PLoS genetics, 8(5), e1002713-e1002713 (2012-06-02)
The functional contribution of CNV to human biology and disease pathophysiology has undergone limited exploration. Recent observations in humans indicate a tentative link between CNV and weight regulation. Smith-Magenis syndrome (SMS), manifesting obesity and hypercholesterolemia, results from a deletion CNV
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