581500

TEMPOL

A stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap.

• Synonym(s): TEMPOL, 4-Hydroxy-TEMPO, 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl
• Empirical Formula (Hill Notation): C₉H₁₈NO₂
• CAS Number: 2226-96-2
• Molecular Weight: 172.24
• MDL number: MFCD00006478
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥97% total nitrogen (N) basis
• form: crystals; powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: orange
• solubility: DMSO: 5 mg/mL; ethanol: soluble; water: soluble
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3
• InChI key: UZFMOKQJFYMBGY-UHFFFAOYSA-N

Description

General description

A stable, cell-permeable nitroxide free radical that acts as a radical scavenger and nitric oxide spin trap. Induces oxidative stress and enhances the levels of p21^WAF1 in HL-60 cells in a dose-dependent manner. Reported to reduce organ injury following hemorrhagic shock. Exhibits radio-protective and anti-proliferative properties.

A stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Induces oxidative stress and enhances the levels of p21^WAF1 in HL-60 cells in a dose-dependent manner. Reported to reduce organ injury following hemorrhagic shock. Exhibits radio-protective and anti-proliferative properties.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Free radical scavenger and nitric oxide spin trap

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Reconstitution

Prepare fresh solutions. Following reconstitution, aliquot and freeze (-20°C).

Other Notes

Gariboldi, M.B., et al. 2000. Free Radic. Biol. Med.29, 633.
Miura, Y., et al. 2000. J. Radiat. Res. (Tokyo)41, 103.
Mota-Filipe, H., et al. 1999. Shock 12, 255.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS05,GHS07,GHS08
• Signal Word: Danger
• Hazard Statements: H302 - H318 - H373
• Precautionary Statements: P260 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): 294.8 °F - DIN 51758
• Flash Point(C): 146 °C - DIN 51758