5.05896

Sumanirole Maleate

• Synonym(s): Sumanirole Maleate, Dopamine D₂ receptor Agonist, Sumanirole, PNU 95666, PNU95666
• Empirical Formula (Hill Notation): C₁₁H₁₃N₃O · xC₄H₄O₄
• CAS Number: 179386-44-8
• Molecular Weight: 203.24 (free base basis)
• MDL number: MFCD09832637
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• potency: 9 nM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: DMSO: 16 mg/mL
• storage temp.: −20°C
• InChI: 1S/C11H13N3O.C4H4O4/c1-12-8-5-7-3-2-4-9-10(7)14(6-8)11(15)13-9;5-3(6)1-2-4(7)8/h2-4,8,12H,5-6H2,1H3,(H,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-/t8-;/m1./s1
• InChI key: VOJRMYBBPKNLLI-ORHWHDKWSA-N

Description

General description

An extremely selective dopamine D₂ receptor agonist (K_i = 9 nM). Commonly used in Parkinson′s Disease models and to reproduce cocaine′s discriminative stimulus effects. Sumanirole has greater than 200-fold selectivity for the D₂ receptor subtype versus the other dopamine receptor subtypes in radioligand binding assays. In cell-based assays, sumanirole is a fully efficacious agonist, with EC₅₀ values between 17 and 75 nM. In animals, sumanirole elicits many physiological responses attributed to D₂-like receptor function.

Warning

Toxicity: Standard Handling (A)

Other Notes

Achat-Mendes, C. et al., 2010. J. Pharmacol. Exp. Ther.334, 556.
McCall, R. B. et al., 2005. J. Pharmacol. Exp. Ther.314, 1248.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable