347436
GGACK
An irreversible inhibitor of urokinase (IC₅₀ 1 µM) and Factor Xa.
Synonym(s):
GGACK, Glu-Gly-Arg-chloromethyl Ketone
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About This Item
Empirical Formula (Hill Notation):
C14H25ClN6O5
Molecular Weight:
392.84
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥80% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
An irreversible inhibitor of urokinase (IC50<1 µM) and Factor Xa.
Biochem/physiol Actions
Cell permeable: no
Primary Target
urokinase
urokinase
Product does not compete with ATP.
Reversible: no
Target IC50: <1 µM against urokinase
Warning
Toxicity: Standard Handling (A)
Sequence
H-Glu-Gly-Arg-CMK
Reconstitution
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Avoid freeze/thaw cycles of stock solution.
Other Notes
Kettner, C., and Shaw, E. 1979. Biochim. Biophys. Acta569, 31.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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