03-32-1501
Z-Phe-Arg-7-amido-4-methylcoumarin, Hydrochloride
Substrate for fluorogenic assay of plasma and glandular kallikreins.
Synonym(s):
Z-Phe-Arg-7-amido-4-methylcoumarin, Hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C33H36N6O6 · xHCl
CAS Number:
Molecular Weight:
612.68 (free base basis)
UNSPSC Code:
12352209
Quality Level
Assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
color
white to off-white
solubility
5% acetic acid: 1 mg/mL
DMSO: 1 mg/mL
water: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
Substrate for fluorogenic assay of plasma and glandular kallikreins. Also serves as a substrate for cathepsin B, cathepsin L, and papain.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Substrate for fluorogenic assay of plasma and glandular kallikreins
Substrate for fluorogenic assay of plasma and glandular kallikreins
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Irritant (B)
Sequence
Z-Phe-Arg-AMC, HCl
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Morita, T., et al. 1977. J. Biochem. 82, 1495.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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T Morita et al.
Journal of biochemistry, 82(5), 1495-1498 (1977-11-01)
Twenty peptide-4-methylcoumarin amides (MCA) were newly synthesized and tested as possible substrates for alpha-thrombin, factor Xa, kallikreins, urokinase, and plasmin. These fluorogenic peptides contained arginine-MCA as the carboxyl-terminus. Release of 7-amino-4-methylcoumarin was determined fluorometrically. Of these peptides, the following were
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