T1512

Tetramisole hydrochloride

powder, ≥99% (TLC)

• Synonym(s): (±)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride
• Empirical Formula (Hill Notation): C₁₁H₁₂N₂S · HCl
• CAS Number: 5086-74-8
• Molecular Weight: 240.75
• Beilstein: 4358989
• EC Number: 225-799-5
• MDL number: MFCD00005536
• UNSPSC Code: 12352202
• PubChem Substance ID: 24278725
• NACRES: NA.77

Properties

• product name: Tetramisole hydrochloride, phosphatase inhibitor
• biological source: synthetic (organic)
• description: alkaline phosphatase inhibitor
• Assay: ≥99% (TLC)
• form: powder
• mp: 266-267 °C (lit.)
• solubility: water: 50 mg/mL, clear, colorless
• SMILES string: Cl[H].C1CN2CC(N=C2S1)c3ccccc3
• InChI: 1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H
• InChI key: LAZPBGZRMVRFKY-UHFFFAOYSA-N

Description

Application

Structure-activity relationship for tetramisole derivatives as alkaline phosphatase inhibitors.

Suitable for inhibition of various mammalian alkaline phosphatases (i.e., liver, kidney, placenta, bone and tumor). Intestinal alkaline phosphatases are only slightly inhibited.

Other Notes

Racemic form of levamisole.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves