SML3842

TAT-SAMβA trifluoroacetate

≥95% (HPLC)

• Synonym(s): SAMβA trifluoroacetate, TAT(47-57)-GG-βIIPKC(624-632) trifluoroacetate, TAT(47-57)-GG-SAMβA trifluoroacetate, YGRKKRRQRRR-GG-RNAENFDRF trifluoroacetate
• Empirical Formula (Hill Notation): C₁₁₈H₁₉₅N₅₁O₃₁ · xC₂HF₃O₂
• Molecular Weight: 2824.13 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: (Powder or Lyophilized powder or film)
• storage condition: desiccated
• color: white to off-white
• storage temp.: -10 to -25°C

Description

Biochem/physiol Actions

TAT-SAMβA is a mitofusin 1 (MFN1)-βIIPKC association blocking peptide that prevents βIIPKC-mediated negative regulation of MFN1. TAT-SAMβA protects neonatal and adult rat cardiac myocytes, but not Mfn1-knockout cells, from stress-induced death in cultures and improves cardiac contractility in rats with heart failure in vivo (3 mg/kg/day for 6 wks via Alzet pump delivery) by re-establishing mitochondrial morphology and function. TAT-SAMβA is composed of a 9-aa βIIPKC-derived MFN1-interacting sequence linked at the N-terminal to the cell permeable TAT(47-57) via a -Gly-Gly- spacer

Caution

Hygroscopic

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable