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SML2170

Sigma-Aldrich

HX531

≥98% (HPLC)

Synonym(s):

4-(5H-2,3-(2,5-dimethyl-2,5-hexano)-5-methyl- 8-nitrodibenzo[b,e][1,4]diazepin-11-yl)benzoic acid, 4-(7,8,9,10-Tetrahydro-5,7,7,10.10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]-diazepin-12-yl)-benzoic acid, HX 531, HX-531

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About This Item

Empirical Formula (Hill Notation):
C29H29N3O4
CAS Number:
Molecular Weight:
483.56
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Pricing and availability is not currently available.

Assay

≥98% (HPLC)

form

powder

color

yellow to orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN(C1=CC2=C(C(C)(CCC2(C)C)C)C=C13)C(C=C4)=C(N=C3C5=CC=C(C=C5)C(O)=O)C=C4[N+]([O-])=O

InChI

1S/C29H29N3O4/c1-28(2)12-13-29(3,4)22-16-25-20(15-21(22)28)26(17-6-8-18(9-7-17)27(33)34)30-23-14-19(32(35)36)10-11-24(23)31(25)5/h6-11,14-16H,12-13H2,1-5H3,(H,33,34)

InChI key

SXKPGYKPQPYJER-UHFFFAOYSA-N

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This Item
GE30152103010350GE30152104010150GE30152105010150
form

suspension (1% Solids)

form

suspension (1% Solids)

form

suspension (1% Solids)

form

suspension (1% Solids)

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

packaging

pkg of 5 mL

packaging

pkg of 100 mL

packaging

pkg of 5 mL

packaging

pkg of 5 mL

ligand

(Streptavidin Coated particles)

ligand

(Streptavidin Coated particles)

ligand

(Streptavidin Coated particles)

ligand

(Streptavidin Coated particles)

Biochem/physiol Actions

HX-531 is a potent antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM. HX531 has been used in many studies of the various effects of retinoids and RXR activity in diseases such as diabetes, Parkinson′s disease, often as a control for agonists such as Bexarotene. It was recently shown to promote white adipogenic differentiation and inhibit both basal and Bexarotene-induced brown adipogenic differentiation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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