Skip to Content
Merck
All Photos(1)

Key Documents

SIRNA

MISSION® siRNA Product Offerings

Custom and Predesigned siRNA

Synonym(s):

Custom siRNA, High-throughput siRNA, Predesigned siRNA, siRNA, siRNA pools

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352208
Fuhui Xu et al.
PloS one, 9(9), e106509-e106509 (2014-09-04)
Improved drought tolerance is always a highly desired trait for agricultural plants. Significantly increased drought tolerance in Arabidopsis thaliana (Columbia-0) has been achieved in our work through the suppression of ESKMO1 (ESK1) gene expression with small-interfering RNA (siRNA) and overexpression
Antonis C Antoniou et al.
The New England journal of medicine, 371(6), 497-506 (2014-08-08)
Germline loss-of-function mutations in PALB2 are known to confer a predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred by such mutations remains unknown. We analyzed the risk of breast cancer among 362 members of
Chong He et al.
PLoS genetics, 10(12), e1004860-e1004860 (2014-12-19)
The common non-steroidal anti-inflammatory drug ibuprofen has been associated with a reduced risk of some age-related pathologies. However, a general pro-longevity role for ibuprofen and its mechanistic basis remains unclear. Here we show that ibuprofen increased the lifespan of Saccharomyces
Maria Dermit et al.
Developmental cell, 55(3), 298-313 (2020-11-11)
Translation of ribosomal protein-coding mRNAs (RP-mRNAs) constitutes a key step in ribosome biogenesis, but the mechanisms that modulate RP-mRNA translation in coordination with other cellular processes are poorly defined. Here, we show that subcellular localization of RP-mRNAs acts as a
Yanli Ma et al.
PloS one, 7(10), e47961-e47961 (2012-11-01)
Aflatoxin B1 (AFB1) is a potent carcinogen that can induce hepatocellular carcinoma. AFB1-8,9-exo-epoxide, one of AFB1 metabolites, acts as a mutagen to react with DNA and induce gene mutations, including the tumor suppressor p53. In addition, AFB1 reportedly stimulates IGF
View All Related Papers

Articles

Dual-Labeled Probes

Dual-Labeled Probes are the most common probe type for qPCR and are often referred to as hydrolysis probes.

Custom Next-Gen Sequencing Oligos

Regardless of next-generation sequencing (NGS) platform, universal and index adapter sequences are required for the proper assembly of sample fragments.

Predesigned siRNA

We and Rosetta Inpharmatics, a recognized leader in Bioinformatics, have partnered to take RNAi research to the next level. Our exclusive siRNAdesign algorithm, licensed from Rosetta Inphamatics, has been optimized with over 3 years of continuous development for enhanced performance in RNAi applications.

Related Content

LightCycler® Probes

LightCycler probes are highly sensitive and sequence-specific fluorescent probes designed for use with the Roche LightCycler instruments.

Custom siRNA Duplex Plates

Use our synthetic, small interfering RNA (siRNA) duplex plates to identify gene function, elucidate pathways, and screen for potential new drug targets.

WellRED Oligos

WellRED oligos use cyanine-based fluorescent dyes with high extinction coefficients that absorb in the near-infrared region, thereby reducing background noise from biological materials, resulting in highly sensitive detection.

Custom Oligos for Commercial Use

As the world’s leading supplier of oligonucleotides, Sigma-Aldrich delivers the largest portfolio of expertise to its diagnostic partners. ISO 13485 & cGMP/ASR certified.

See All

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service